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- 27Alzheimer's disease
- 4Dementia
- 3Amyloid precursor protein
- 3Cognitive impairment
- 3Interventions
- 31Graduate and Postdoctoral Studies (GPS), Faculty of
- 31Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 13Nursing, Faculty of
- 7Nursing, Faculty of/Chronicity
- 4Biological Sciences, Department of
- 4Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...
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Spring 2018
Critical care nephrology is a rapidly growing and developing field within critical care medicine. It encompasses the entire spectrum of mild acute kidney injury (AKI), usually represented by a change in biochemical markers (i.e., serum creatinine and urea) or alterations in clinical parameters...
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Quality indicators for patients presenting to emergency departments with cerebrovascular events: A chart review and prospective study of transient ischemic attacks and stroke within the Alberta Health Services-Edmonton Zone
DownloadSpring 2013
This thesis presents the results from a retrospective chart review of medical records and a prospective patient interview of stroke patients within the AHS Edmonton-Zone emergency departments. Of 7330 charts reviewed, 17% had a diagnosis other than stroke/TIA (misclassified). Of the 336 patients...
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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2011
Barnard, D., Norton, P.G., Cranley, L.A., Estabrooks, C.A., Cummings, G.G.
Background: The current profile of residents living in Canadian nursing homes includes elder persons with complex physical and social needs. High resident acuity can result in increased staff workload and decreased quality of work life. Aims: Safer Care for Older Persons [in residential]...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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Tapeworm (Hymenolepis diminuta) infection in flour beetles (Tribolium confusum): does it cause a trade-off between host fecundity and egg size?
Download2009
Inter- and intra-specific comparisons commonly reveal an inverse relationship between fecundity and offspring size. Many animals also vary egg size in response to environmental conditions. Infection of flour beetles Tribolium confusum Jaquelin Du Val, 1868 with the rat tapeworm Hymenolepis...
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2011
Slaughter, S., Bostrom, A.M., Cummings, G.G., Morgan, D.G., Estabrooks, C.A., Norton, P.G., Squires, J.E.
Background: Defining what constitutes a resident care unit in nursing home research is both a conceptual and practical challenge. The aim of this paper is to provide evidence in support of a definition of care unit in nursing homes by demonstrating: (1) its feasibility for use in data collection,...
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The north is not all the same: comparing health system performance in 18 northern regions of Canada
Download2019-11-29
Young, T. Kue, Chatwood, Susan, Ng, Carmina, Young, Robin, W., Marchildon, Gregory, P.
"We investigated the availability of health system performance indicator data in Canada’s 18 northern regions and the feasibility of using the performance framework developed by the Canadian Institute for Health Information [CIHI]. We examined the variation in 24 indicators across regions and...