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Spring 2010

Kodam, Anitha

The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...

Spring 2013

Maulik, Mahua

Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...

Fall 2013

Sivakumar, Leka

Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods:...

Fall 2018

Chenji, Sneha R.

Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...

Spring 2024

Drouin, Shannon

Objective We apply data-driven approaches to identify predictors of heterogeneous trajectories across normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease (AD). In Study 1, we investigated predictors of left and right hippocampal (HC) volume trajectory classes. In Study 2, we...

Fall 2018

Al Onazi, Mona Moraybed

Introduction: More than one in five women who survive breast cancer will eventually develop lymphedema. Recent studies in breast cancer lymphedema management have demonstrated that resistance exercise can improve the survivors’ quality of life without exacerbating their lymphedema. However,...

Fall 2019

Kebbe, Maryam

Background. Given adolescents’ increasing desire for independence and autonomy, there is a need for research to examine their lived experiences, including concerns, preferences, and priorities. In the context of lifestyle modification for weight management, most adolescents with obesity exhibit...

Fall 2014

Lampe, William L

In general, chronic endurance training has positive effects on physiological function. However, the performance of training in excess of what an individual is able to recover from can lead to performance, physiological and psychobiological maladaptation. The purposes of this investigation were to...

Fall 2019

Munan, Matthew J.

Background: It is well known that exercise can improve glycemic control in individuals with type 2 diabetes (T2D). However, the glycemic response to exercise is highly variable. One of the primary causes of variability in response to a single bout of exercise may be timing in relation to meals....

Spring 2017

McComb, Alyssa D

Introduction: Elderly individuals who are hospitalized due to emergency abdominal surgery spend on average over 80% of their recovery time in bed, resulting in early and rapid muscle loss. As these elderly individuals have a lower physiological reserve, the impact of muscle wasting on function...