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Fall 2021
The field of animal personality, the study of adaptive among-individual behavioural differences in animal populations, has both exploded in popularity in the last few decades and come under heavy scrutiny by behavioural ecologists. The sudden interest in the field stems from the widespread...
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Fall 2013
Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods:...
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Fall 2018
Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...
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2019-01-01
Yardley, J. E., Houlder, S. K.
Prior to the widespread use of continuous glucose monitoring (CGM), knowledge of the effects of exercise in type 1 diabetes (T1D) was limited to the exercise period, with few studies having the budget or capacity to monitor participants overnight. Recently, CGM has become a staple of many...
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2019-11-13
Houlder, S. K., Yardley, J. E.
Prior to the widespread use of continuous glucose monitoring (CGM), knowledge of the effects of exercise in type 1 diabetes (T1D) was limited to the exercise period, with few studies having the budget or capacity to monitor participants overnight. Recently, CGM has become a staple of many...
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Coordinated distributed experiments: An emerging tool for testing global hypotheses in ecology and environmental science
Download2013-01-01
Knapp, A. K., Collins, S. L., Turkington, R. , Long, R., White, S., Cahill, J. F., Carlyle, C. N., Beierkuhnlein, C., Luo, Y., Casper, B. B. Cleland, E., Lind, E., Smith, M. D., Henry, H. A. L., Dukes, J. S., Fraser, L. H., Reich, P. B., Sternberg, M.
There is a growing realization among scientists and policy makers that an increased understanding of today's environmental issues requires international collaboration and data synthesis. Meta-analyses have served this role in ecology for more than a decade, but the different experimental...
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Coordinated Distributed Experiments: an emerging tool for testing global hypotheses in ecology and environmental science
Download2013
Carlyle, C. N., Henry, H. A. L., Fraser, L. H.
There is a growing realization among scientists and policy makers that an increased understanding of today's environmental issues requires international collaboration and data synthesis. Meta-analyses have served this role in ecology for more than a decade, but the different experimental...