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Skip to Search Results- 1Al-Nuaimi, Saleem K
- 1Arvanitidis, Anastasia P
- 1Budd, Alexandra
- 1Connor, Steven
- 1Engin, Elif
- 1Greenberg, Anastasia
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Characterisation of the sleep-related slow oscillation in the neocortical - entorhinal - hippocampal bidirectional circuit
DownloadFall 2009
Our ability to recall information and events is astounding and dependent on the medial temporal lobe (MTL) memory system. The synaptic interconnections between the neocortex (nCTX), entorhinal cortex (EC), and hippocampus (HPC) are the anatomical basis of this memory system. The...
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Spring 2016
Hippocampal activity is characterized by two state-dependent, mutually exclusive large-amplitude oscillations: theta (3-12 Hz) and the hippocampal slow oscillation (SO; ~1 Hz). These two rhythms have been implicated in different stages of memory processing. Theta occurs during awake exploratory...
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Fall 2016
Oscillations are a fundamental principle of neural operation, organized into a hierarchy of frequency bands with the dominant rhythm alternating within and across behavioral states. During states of sleep and anesthesia, brain activity in forebrain regions displays two major distinct activity...
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Hippocampal Diffusion Tensor Imaging in Parkinson's Disease and Associations with Non- Motor Symptoms
DownloadSpring 2023
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and causes not only well-characterised motor symptoms, but also a host of non-motor symptoms that greatly impact quality of life. PD exists within a larger spectrum of disorders caused by the accumulation of Lewy bodies...
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Hippocampal neuroplasticity and neurogenesis in major depressive disorder: a high field MRI study
DownloadFall 2012
The hippocampus is a brain structure responsible for memory, learning, and the stress response; it is also used as a model for major depressive disorder (MDD) in preclinical studies. Preclinical models have shown that the hippocampal subfields are differentially affected by chronic stress....
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Investigating Human Brain Function and Human Brain Organization Using Functional Magnetic Resonance Imaging at 4.7 T
DownloadFall 2020
Understanding the brain-cognition association has been a major goal of neuroscientists for more than 50 years. The discovery of functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) contrast by Ogawa and colleagues (1990, 1992) has fundamentally transformed the field of...
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Fall 2019
Acquisition and storage of episodic-like information fundamentally contributes to quality of life. It is the type of information that allows us to remember meaningful events such as our graduation and our heartaches. The memory of these events allows us to adapt our behaviours to facilitate more...
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Magnetic Resonance Imaging of the Brain in Prenatal Alcohol Exposure and Advances in Measuring Cortical Microstructure
DownloadFall 2020
Fetal alcohol spectrum disorder (FASD) encompasses a large spectrum of physical, cognitive and behavioral deficits resulting from prenatal alcohol exposure. Studies using magnetic resonance imaging (MRI) have shown structural and functional brain alterations in children and adolescents with...
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Modulation of Spontaneous Neural Network Bursting in Newborn Rat Brain Slices by Extracellular Calcium, Methylxanthines, and Opioids
DownloadFall 2012
Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...
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Fall 2011
The ability of synapses to undergo lasting changes in synaptic strength is considered the primary cellular mechanism for associative memory formation in the mammalian brain. Synapses in the hippocampus, a brain structure required for new memory genesis, exhibit a remarkable capacity for...