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Skip to Search Results- 1Allen, Felicity R
- 1Bastani, Meysam
- 1Bostan, Babak
- 1Eastman, Thomas
- 1Heydari, Maysam
- 1Khan, Sheehan Veikko
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Spring 2010
This thesis presents Pathway Informed Analysis (PIA), a classification method for predicting disease states (diagnosis) from metabolic profile measurements that incorporates biological knowledge in the form of metabolic pathways. A metabolic pathway describes a set of chemical reactions that...
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Spring 2016
One of the key obstacles to the effective use of mass spectrometry (MS) in high throughput metabolomics is the difficulty in interpreting measured spectra to accurately and efficiently identify metabolites. Traditional methods for automated metabolite identification compare the target MS spectrum...
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Fall 2012
Functional Magnetic Resonance Imaging (fMRI) measures the dynamic activity of each voxel of a brain. This dissertation addresses the challenge of learning a diagnostic classifier that uses a subject’s fMRI data to distinguish subjects with neuropsychiatric disorders from healthy controls. fMRI...
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Fall 2009
In this thesis we consider the task of catching a moving target with multiple pursuers, also known as the “Pursuit Game”, in which coordination among the pursuers is critical. Our testbed is inspired by the pursuit problem in video games, which require fast planning to guarantee fluid frame...
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Spring 2014
Each patient with Type-1 diabetes must decide how much insulin to inject before each meal to maintain an acceptable level of blood glucose. The actual injection dose is based on a formula that takes current blood glucose level and the meal size into consideration. While following this insulin...
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Fall 2009
Understanding biochemical reactions inside cells of individual organisms is a key factor for improving our biological knowledge. Signaling pathways provide a road map for a wide range of these chemical reactions that convert one signal or stimulus into another. In general, each signaling pathway...
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Fall 2009
This thesis addresses the challenge of prognosis, in terms of survival prediction, for patients with Glioblastoma Multiforme brain tumors. Glioblastoma is the most malignant brain tumor, which has a median survival time of no more than a year. Accurate assessment of prognostic factors is critical...
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Fall 2015
Researchers conduct association studies to discover biomarkers in order to gain new biological insight on complex diseases and phenotypes. Although most researchers have intuitions about what defines a biomarker and how to assess the results of an association study, there is neither a formal...
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The challenge of applying machine learning techniques to diagnose schizophrenia using multi-site fMRI data
DownloadSpring 2017
One of the main challenges for the use of machine learning techniques in neuroimaging data is the small n, large p problem. Datasets usually contain only a few hundreds of instances (n), each of which is described using hundreds of thousands of features (p). In this dissertation, we explore the...