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Fall 2012

Ebadi, Maryam

Mechanisms underlying fat loss in cancer are not well understood. Knowing the types of fat being lost from adipose tissue may help define interventions to circumvent wasting. The aim of this study was to explore the differences in adipokines and fatty acid composition between visceral adipose...

Spring 2010

Mohammed, Riazuddin

Biosynthesis of milk conjugated linoleic acid (CLA), a component of milk fat with demonstrated health benefits, requires a dietary source of PUFA. Even with PUFA supplementation, milk CLA is highly variable. Therefore, this study was aimed at identifying factors responsible for the variations in...

Spring 2018

Just, Timothy P

The purpose of this thesis was to investigate whether sex and estrogen modulate sympathetic neurovascular control in resting and contracting skeletal muscle. This thesis also investigated the hypothesis that the effects of sex and estrogen on neurovascular control would be mediated by the signal...

2010

Godbout, Roseline, Mita, Raja, Field, Catherine J., Beaulieu, Michael J.

Malignant gliomas (MG) are highly infiltrative tumors that consistently recur despite aggressive treatment. Brain fatty acid-binding protein (FABP7), which binds docosahexaenoic acid (DHA) and arachidonic acid (AA), localizes to sites of tumor infiltration and is associated with a poor prognosis...

Fall 2015

Normandeau, Christopher M.

There is a concern that brain tumours are underreported in the Alberta Cancer Registry (ACR), yet no studies have been performed to investigate this issue. This study addresses the concern of underreporting of brain tumours in the ACR by assessing case ascertainment of primary brain tumours cases...

2007

Williams, J. L., Moore, S. S., Wang, Z., McKay, S. D., Murdoch, B. M.

High-density whole-genome maps are essential for ordering genes or markers and aid in the assembly of genome sequence. To increase the density of markers on the bovine radiation hybrid map, and hence contribute to the assembly of the bovine genome sequence, an Illumina® BeadStation was used to...

2012

Dobrinsky, John, Zhou, Chi, Pasternak, J. Alexander, Dyck, Michael K., Foxcroft, George R., Nieminen, Julie, Tsoi, Stephen, Rigault, Philippe, Sirard, Marc-André, Robert, Claude, Grant, Jason R.

Background The domestic pig is an important livestock species and there is strong interest in the factors that affect the development of viable embryos and offspring in this species. A limited understanding of the molecular mechanisms involved in early embryonic development has inhibited our...

Fall 2022

Collison, Breanne

Contraction-mediated inhibition of sympathetic vasoconstriction (sympatholysis) is enhanced in female compared with male rats. Acute pharmacological blockade of nitric oxide (NO) production abolished the sex difference in sympatholysis, indicating that NO-mediated sympatholysis is elevated in...

Spring 2014

Kelly, Karen

Mandatory folate fortification polices in North America have resulted in high levels of circulating folate in the population. At the same time, a trend toward increased energy intake and reduced energy expenditure has lead to an increased prevalence of obesity, characterized by an accumulation of...

Fall 2012

Wan, Zhongxiao

The biochemical and molecular mechanisms underlying the beneficial effects of exercise remain elusive. Growing evidence suggests that white adipose tissue (WAT) is an important organ that exercise exerts beneficial effects on. The role of interleukin 6 (IL-6) in mediating WAT metabolism remains...