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The current recommended vitamin D intake guideline for diet and supplements during pregnancy is not adequate to achieve vitamin D sufficiency for most pregnant women
Download2016
Maggiore, Jack A., Eliasziw, Misha, Rabi, Doreen, O'Beirne, Maeve, Field, Catherine J., Hanley, David A., Dewey, Deborah, Aghajafari, Fariba, Weinberg, Amy, Kaplan, Bonnie J., Ross, Sue
Background The aims of this study were to determine if pregnant women consumed the recommended vitamin D through diet alone or through diet and supplements, and if they achieved the current reference range vitamin D status when their reported dietary intake met the current recommendations....
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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Transcriptional regulation of lipid metabolism: A key determinant of pancreatic ß-cell function
Download2005
Fatehi-Hassanabad, Zahra, Chan, Catherine B.
Background Optimal pancreatic β-cell function is essential for the regulation of glucose homeostasis in both humans and animals and its impairment leads to the development of diabetes. Type 2 diabetes is a polygenic disease aggravated by environmental factors such as low physical activity or a...
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2015
Stothard, Paul, Wang, Yining, Lin, Guohui, Wylie, Tim
Background Despite ongoing reductions in the cost of sequencing technologies, whole genome SNP genotype imputation is often used as an alternative for obtaining abundant SNP genotypes for genome wide association studies. Several existing genotype imputation methods can be efficient for this...
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Whole-genome analyses of Korean native and Holstein cattle breeds by massively parallel sequencing
Download2014
Kim, Tae-Hun, Oh, Jae-Don, Han, Kwang-Jin, Choi, Jung-Woo, Choi, So-Young, Lee, Hak-Kyo, Stothard, Paul, Jeon, Heoyn-Jeong, Lee, Kyung-Tai, Lee, Jeong-Koo, Jeong, Dongkee, Kim, Namshin, Chung, Won-Hyong, Kim, Hyeong-Cheol, Liao, Xiaoping, Yang, Bokyoung, Miller, Stephen P., Lee, Sung-Jin
A main goal of cattle genomics is to identify DNA differences that account for variations in economically important traits. In this study, we performed whole-genome analyses of three important cattle breeds in Korea—Hanwoo, Jeju Heugu, and Korean Holstein—using the Illumina HiSeq 2000 sequencing...