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Transcriptional regulation of lipid metabolism: A key determinant of pancreatic ß-cell function
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- Author(s) / Creator(s)
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Background Optimal pancreatic β-cell function is essential for the regulation of glucose homeostasis in both humans and animals and its impairment leads to the development of diabetes. Type 2 diabetes is a polygenic disease aggravated by environmental factors such as low physical activity or a hypercaloric high-fat diet. Results Free fatty acids represent an important factor linking excess fat mass to type 2 diabetes. Several studies have shown that chronically elevated free fatty acids have a negative effect on β-cell function leading to elevated insulin secretion basally but with an impaired response to glucose. The transcription factors PPARα, PPARγ and SREBP-1c respond to changing fat concentrations in tissues, thereby coordinating the genomic response to altered metabolic conditions to promote either fat storage or catabolism. These transcription factors have been identified in β-cells and it appears that each may exert influence on β-cell function in health and disease. Conclusion The role of the PPARs and SREBP-1c as potential mediators of lipotoxicity is an emerging area of interest.
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- Date created
- 2005
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- Subjects / Keywords
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- Type of Item
- Article (Published)
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- License
- Attribution 4.0 International