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Skip to Search Results- 1Chaurasiya, Shyambabu
- 1DeSilva, Alan D
- 1Elamy, Abdel-Halim H
- 1Lamey, Michael
- 1MacLeod, Sheena H
- 1Miklavcic, John
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Fall 2013
Hepatocellular carcinoma (HCC) is the fifth most common cancer and third leading cause of cancer-related deaths. Due to the low response to current HCC therapy, many studies have been done to identify novel HCC therapeutics. Non-replicating first generation adenovirus (Ad) vectors and...
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Binding, internalization, and transgene expression of an adenoviral vector retargeted to HER3/4
DownloadFall 2013
Adenoviruses (Ads) have been well studied for use in cancer gene therapy. However, low levels of the primary receptor, coxsackie-adenovirus receptor (CAR), in tumor cells has been shown to be a factor in low transgene expression. To increase Ad infection of breast cancer cells we constructed a...
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Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography
DownloadFall 2012
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...
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Effect of Adenovirus-mediated Decorin Gene Therapy on Fibrotic Remodeling in Tissue-engineered Skin
DownloadFall 2016
Background: Hypertrophic scar (HTS) is a fibroproliferative disorder of the skin that results in the development of painful, red, raised scar lesions. Transforming growth factor beta 1 (TGF-β1) has been implicated as a key driver of this disorder. Primarily, these effects include an increased...
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Epidemiological Characteristics and Ecological Investigation of the 2009 Influenza Pandemic
DownloadFall 2014
Influenza pandemic occurs when a novel influenza virus subtype for which humans do not have sufficient immunity emerges and spreads quickly from person-to-person worldwide. Influenza pandemics result in serious consequences on human health and economy. In April 2009, the World Health Organization...
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Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitro
DownloadFall 2009
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
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Impact of conventional fractionated RT to pelvic lymph nodes and dose-escalated hypofractionated RT to prostate gland using IMRT treatment delivery in high-risk prostate cancer
DownloadFall 2009
Prostate cancer is the most common cancer among Canadian men. The standard treatment in high-risk category is radical radiation, with androgen suppression treatment (AST). Significant disease progression is reported despite this approach. Radiation dose escalation has been shown to improve...
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Spring 2010
A prototype system which has integrated a linear accelerator (linac) with a magnetic resonance imager (MRI) has been constructed at the Cross Cancer Institute. The real time operation of a linac-MRI system will require proper radio frequency (RF) shielding such that the MRI images can be acquired...
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Fall 2016
Breast cancer (BrCa) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. Current therapies for BrCa are insufficient to cure metastatic disease and are often associated with debilitating side effects that severely deteriorate the quality of patients’...