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Skip to Search Results- 52Mass-spectrometry
- 22Molecular-dynamics
- 8Metabolomics
- 6Cytotoxicity
- 5Electrospray ionization
- 4Classification
- 6Klassen, John S.
- 4Kitova, Elena N.
- 3Han, Ling
- 2Armstrong, Glen D.
- 2Dingle, Tanis C.
- 2El-Hawiet, Amr
- 63Graduate and Postdoctoral Studies (GPS), Faculty of
- 63Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 7Chemistry, Department of
- 7Chemistry, Department of/Journal Articles (Chemistry)
- 3Biological Sciences, Department of
- 3Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Fall 2016
α-Synuclein has been implicated in the progression of Parkinson’s disease, a neurodegenerative disorder that affects millions of people worldwide. This work reports on the structural propensity and druggability of this protein using a combination of Monte Carlo, Molecular Dynamics, and Virtual...
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Fall 2015
Microtubules are cellular structures that are crucial to many cellular functions including maintenance of cell shape, vesicular transport, and cell division. The dynamic instability of microtubules is the basic feature which enables them to do their cellular functions. Their pivotal role in cell...
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Cytotoxicity, mutagenicity, and genotoxicity of emerging drinking water disinfection byproducts
DownloadSpring 2014
Drinking water disinfection byproducts (DBPs) are formed unintentionally when organic matter in raw water reacts with disinfectants used to kill pathogens. Epidemiological studies have shown that an increased risk of bladder cancer is associated with consumption of chlorinated water, but little...
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Design of Macromolecular Anti-cancer Drug Delivery Systems using Molecular Dynamics Simulation
DownloadFall 2015
In recent years, the application of self-associating block copolymer based drug delivery systems has attracted increasing attention as nano-sized carriers for the encapsulation and the controlled delivery of water insoluble drugs. Most of the drug formulations are based on the “trial and error”...
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2016
Klassen, John S., Han, Ling, Kitova, Elena N.
This study reports on the use of the catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS) assay, combined with glycomicelles, as a method for detecting specific interactions between water-soluble proteins and glycolipids (GLs) in aqueous solution. The B subunit homopentamers...
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2016
Han, Ling, Klassen, John S., Kitova, Elena N.
This study reports on the use of the catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS) assay, combined with glycomicelles, as a method for detecting specific interactions between water-soluble proteins and glycolipids (GLs) in aqueous solution. The B subunit homopentamers...
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Development and Application of Chemical Isotope Labeling Methods for Metabolomics Data Processing and Liquid Chromatography-Mass Spectrometry-Based Metabolomics
DownloadSpring 2016
Metabolomics is the study of chemical processes involving small-molecule metabolites in a given biological system. These small molecules are downstream outputs of cellular activities. An understanding of the metabolome change can help us to visualize perturbations in the genome or proteome from...
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Development and Application of ESI-MS Based Techniques for Quantitative Determination of Protein-Carbohydrate Interactions
DownloadFall 2016
This thesis describes the development and application of mass spectrometry methods to study protein-ligand interactions in vitro. Liquid sample desorption electrospray ionization mass spectrometry (liquid sample DESI-MS) was employed to quantify protein-carbohydrate interactions in aqueous buffer...
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Development and application of mass spectrometry for bioanalysis of proteins and metabolites
DownloadSpring 2011
The proteome, a hybrid term from protein and genome, is the total set of proteins expressed by a genome in a cell, tissue, or organism at a given time. Proteomics, the study of the proteome, is concerned with a variety of topics such as identity, quantity, activity, structure, protein-protein...