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Skip to Search Results- 1Barakat, Khaled H.
- 1Clive, Derrick L. J.
- 1Fagan-Garcia, Katharine
- 1Fliegel, Larry
- 1Li, Jing
- 1Li, Liang
- 5Graduate and Postdoctoral Studies (GPS), Faculty of
- 5Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 1Biochemistry, Department of
- 1Biochemistry, Department of/Journal Articles (Biochemistry)
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A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signaling
DownloadFall 2010
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
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Computational High Throughput Screening Targeting DNA Repair Proteins To Improve Cancer Therapy
DownloadSpring 2012
Developing a new drug is a complex, highly structured, and expensive task. The further a potential drug progresses in the development process, the more costly its failure becomes. Virtual screening (VS) is the initial stage of a drug discovery process. Its job is to screen large compound...
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Differences in replication of a DNA template containing an ethyl phosphotriester by T4 DNA polymerase and Escherichia coli DNA polymerase I
Download2003
Reha-Krantz, L.J., Tsujikawa, L., Weinfield, M.
A DNA template containing a single ethyl phosphotriester was replicated in vitro by the bacteriophage T4 DNA polymerase and by Escherichia coli DNA polymerase I (DNA pol I). Escherichia coli DNA pol I bypassed the lesion ef®ciently, but partial inhibition was observed for T4 DNA polymerase. The...
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Spring 2016
Carbohydrates play vital roles in many disease pathologies, including inflammatory disease, cancer metastasis, autoimmune disease and pathogenic infection. Despite their significance and immense opportunity for pharmaceutical application, carbohydrate-derived drugs only constitute a relatively...
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Mitogen-activated protein kinase-dependent activation of the na+/H+ exchanger is mediated through phosphorylation of amino acids ser(770) and ser(771)
Download2007-01-01
Malo, Mackenzie E., Li, Liang, Fliegel, Larry
We investigated regulation of the type 1 isoform of the Na+/H+ exchanger by phosphorylation. Four specific groups of serine and threonine residues in the regulatory carboxyl-terminal tail were mutated to alanine residues: group 1, S693A; group 2, T718A and S723A/S726A/S729A; group 3,...
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Fall 2016
Membrane transporters play integral roles in the functioning of cells by controlling movement of molecules across the phospholipid bilayer. In this thesis, utilization of radioisotope uptake assays permitted examination of intentional and unintentional inhibition of three membrane transporter...
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Spring 2010
Tuberculosis (TB) is the disease arising from infection by Mycobacterial tuberculosis and kills millions of people every year. Difficulties in the treatment of TB and the emergence of multiple-drug resistant and extreme-drug resistant M. tuberculosis strains have increased interest in finding...
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Synthesis of Substituted Resorcinol Monomethyl Ethers from 2-Bromo-3-methoxycyclohex-2-en-1-ones
Download2015-01-01
Shao, Wenjie, Clive, Derrick L. J.
2-Bromo-3-methoxycyclohex-2-en-1-ones are readily alkylated at C-6 with reactive halides, and then treatment with DBU (2 equiv) in PhMe at room temperature results in smooth loss of bromide and aromatization to resorcinol (monomethyl ethers of defined substitution pattern.