Search
Skip to Search Results- 2Curtis, Jonathan M.
- 1Barnes, Peter J.
- 1Benesch, Matthew G. K.
- 1Brindley, David N.
- 1Ito, Kazuhiro
- 1Kimura, Genki
- 1Antioxidants
- 1Autotaxin Inhibition
- 1Chronic Obstructive Pulmonary Disease
- 1Cytokines
- 1Dimers (Chemical Physics)
- 1Fluorescent Substrate-3 Assay
-
Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers
Download2014
Ueda, Keitaro, Ito, Kazuhiro, Kimura, Genki, Moses, Audric, Xiong, Yeping, Kizawa, Yasuo, Curtis, Jonathan M., Barnes, Peter J., Mercado, Nicolas
Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellular senescence. However, Nrf2...
-
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate
Download2015
Zhao, Yuan Y., McMullen,Todd P. W. , Brindley, David N., Curtis, Jonathan M., Benesch, Matthew G. K.
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is also involved in wound healing and...