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Skip to Search Results- 10Stimuli-Responsive Polymers
- 7Etalons
- 3Phase-Transition
- 3Photonic Materials
- 3Protein-Concentration
- 2Poly (N-isopropylacrylamide)-Based Microgels
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Controlled drug release from the aggregation–disaggregation behavior of pH-responsive microgels
Download2014-01-01
Gao, Yongfeng, Ahiabu, Andrews, Serpe, Michael J.
In this submission, two independent sets of microgels were synthesized that exhibit pH responsivity over different solution pH ranges. The microgels were synthesized by copolymerizing two different comonomers with poly(N-isopropylacrylamide) (pNIPAm). The microgels copolymerized with acrylic acid...
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2015
Guo, Siyuan, Zhang, Qiang M., Serpe, Michael J., Wei, Menglian, Gao, Yongfeng
A device constructed by sandwiching a thin film of poly(N-isopropylacrylamide)-co-acrylic acid (pNIPAmco-AAc) microgels between two thin layers of Au (all on a glass support) was used as a novel platform for controlled release of small molecules (drugs). In this submission, the model drug tris...
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Isolation of RNA from a mixture and its detection by utilizing a microgel-based optical device
Download2018-01-01
Islam, Molla R., Azimi, Shakiba, Teimoory, Faranak, Loppnow, Glen R., Serpe, Michael J.
In this investigation, we show that RNA can be separated from a solution containing DNA and RNA and the isolated RNA can be detected using poly (N-isopropylacrylamide-co-N-(3-aminopropyl) methacrylamide hydrochloride) microgel-based optical devices (etalons). The isolation of RNA was accomplished...
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2017-01-01
Zhang, Qiang, Colazo, Juan, Berg, Darren, Mugo, Samuel M., Serpe, Michael J.
Nanogels with a biomolecular coating (biocoating) were shown to be capable of triggered delivery of anticancer drug Doxorubicin. The biocoating was formed utilizing binding between glycogen and the tetra-functional lectin Concanavalin A, which can be triggered to disassemble (and release) upon...
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2012
Poly (N-isopropylacrylamide) (pNIPAm) is one of the most completely studied “smart” polymers due to its unique reversible thermoresponsivity. That is, when pNIPAm in water is heated > ~31°C, it transits from a random coil to a globule conformation; this transition is reversed when T < ~31°C. This...
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Poly (N-isopropylacrylamide) microgel-based etalons for the label-free quantitation of estradiol-17β in aqueous solutions and milk samples
Download2018-01-01
Jiang, Yaxin, Colazo, Marcos G., Serpe, Michael J.
A novel estradiol-17β (E2) biosensor was constructed from poly(N-isopropylacrylamide) (pNIPAm) microgel-based etalons by modification of their outermost Au layer with an E2 binding 75-mer DNA aptamer. When E2 is not present in the solution, the aptamer forms a loose/linear structure that allows...
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2014
Ahiabu, Andrews, Islam, Molla R., Li, Xue, Serpe, Michael J.
Responsive polymer-based materials have found numerous applications due to their ease of synthesis and the variety of stimuli that they can be made responsive to. In this review, we highlight the group’s efforts utilizing thermoresponsive poly (N-isopropylacrylamide) (pNIPAm) microgel-based...
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2016-01-01
Jiang, Yaxin, Colazo, Marcos G., Serpe, Michael J.
Progesterone (P4) is a vital steroid hormone involved in the reproduction cycle and necessary for maintenance of pregnancy in humans and animals. Monitoring P4 concentrations is required in various fields, such as dairy industry, environmental protection, and clinical laboratories. The current...
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2014
Serpe, Michael J., Islam, Molla R.
In this submission we fabricated a humidity-responsive polymer-based actuator by layering negatively charged poly(N-isopropylacrylamide)-co-acrylic acid microgels and positively charged poly(diallyldimethyl ammonium chloride) on top of a flexible plastic substrate. We show that the extent of the...
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Polymer-based devices for the label-free detection of DNA in solution: low DNA concentrations yield large signals
Download2014-01-01
Islam, Molla R., Serpe, Michael J.
Poly (N-isopropylacrylamide-co-N-(3-aminopropyl) methacrylamide hydrochloride) microgel-based optical devices (etalons) have been shown to change their optical properties in the presence of single-stranded DNA. We hypothesize that this is due to the negatively charged DNA penetrating through the...