Multi responsive nanogels for targeted anticancer drug delivery

• Author(s) / Creator(s)

  • Zhang, Qiang
  • Colazo, Juan
  • Berg, Darren
  • Mugo, Samuel M.
  • Serpe, Michael J.

• Nanogels with a biomolecular coating (biocoating) were shown to be capable of triggered delivery of anticancer drug Doxorubicin. The biocoating was formed utilizing binding between glycogen and the tetra-functional lectin Concanavalin A, which can be triggered to disassemble (and release) upon exposure to glucose and changes in solution pH. We also show the nanogel’s thermoresponsivity can be used to accelerate Doxorubicin release. Moreover, we showed that transferrin immobilized on the nanogel surface could accelerate nanogel uptake by cancer cells. In these experiments, we showed that Doxorubicin was able to be released to the nucleus of human liver cancer cell line (HepG2) within 3 h. Doxorubicin-loaded nanogels exhibit a strong growth inhibition ability toward HepG2. This investigation showcases how nanogel design and chemistry can be tuned to achieve useful biomedical applications.

• Date created

  2017-01-01

• Subjects / Keywords

  • Stimuli-Responsive Polymers
  • Biomolecular Coatings
  • Drug Delivery
  • Nanogels

• Type of Item

  Article (Draft / Submitted)

• DOI

  https://doi.org/10.7939/r3-x4v2-ns19

• License

  © American Chemical Society, 2017. This is an open access article which is free to download and share.