Feeding high oleic acid Canola oil or olive oil alters inflammation, insulin resistance and lipid metabolism in a rodent model of diet induced obesity

  • Author / Creator
    Ruby, Kelsi
  • To determine the efficacy of feeding monounsaturated fatty acids (MUFA) via a high MUFA Canola oil on T2D risk factors diet induced obese rats were fed either a low fat diet (LF), a high fat low MUFA diet (HF), a high fat high MUFA olive oil diet (OO), or a high fat high MUFA Canola oil diet (HCO) diet for 4 weeks. The effect on immune function, insulin sensitivity and the fatty acid composition of phospholipids (PL) and stored lipids were measured. Increasing MUFA in the diet resulted in a lower (p<0.05) production of pro-inflammatory cytokines compared to HF; however, OO had a greater (p<0.05) effect compared to HCO. Feeding OO led to significantly greater (p<0.05) proportions of oleic and linoleic acid compared to feeding HCO in spleen PL. In summary, dietary MUFA altered lipid metabolism and lowered the pro-inflammatory response; however, HCO and OO were not equivalent. In a diet of similar fatty acid composition, feeding MUFA from OO was more effective in dampening the pro-inflammatory response by immune cells in obese rats.

  • Subjects / Keywords
  • Graduation date
    Fall 2011
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.