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Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: A systematic reviewDownload
Opioid-induced constipation (OIC) is an unpleasant and ubiquitous side effect of opioid treatment. Ineffective treatment of OIC can result in decreased adherence to opioid therapy, decreased quality of life, and increased morbidity and mortality. The constipating effects of opioids result from...