- 167 views
- 192 downloads
Gut microbiota modulation with long-chain corn bran arabinoxylan in overweight individuals is linked to individualized temporal increase in fecal propionate
-
- Author / Creator
- Nguyen, Nguyen
-
Variability in the health effects of dietary fibers (DFs) might arise from inter-individual differences in the microbiome’s ability to ferment these substrates into beneficial metabolites. However, our understanding of what drives this individuality is vastly incomplete. Here, we report results from a parallel-arm, randomized controlled trial aimed to characterize the effects of a long-chain, complex arabinoxylan (AX) isolated from corn bran on gut microbiota composition and short-chain fatty acid (SCFA) production as compared to microcrystalline cellulose (non-fermentable control). AX resulted in a global shift in the fecal bacterial community and the promotion of specific taxa, including OTUs related to Bifidobacterium longum, Blautia obeum, and Prevotella copri. AX further increased fecal propionate concentration (overall effect p=0.015, Friedman’s test), an effect that showed two distinct temporal responses that allowed grouping of participants. The two groups showed significant differences in compositional shifts of the microbiome (p≤0.025, PERMANOVA), and multiple linear regression analyses revealed that the propionate response was predictable through shifts, and to a lesser degree, baseline composition of the microbiota. Pre-treatment dietary history was unable to predict the response. This study showed that individualized metabolic effects of DF on the gut microbiota are linked to both compositional shifts and its baseline composition, providing preliminary evidence that such responses might be predictable.
-
- Subjects / Keywords
-
- Graduation date
- Spring 2020
-
- Type of Item
- Thesis
-
- Degree
- Master of Science
-
- License
- Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.