Evaluating Therapies and Outcomes in Acute and Chronic Heart Failure

  • Author / Creator
    Almajed, Nawaf S
  • Heart failure is common, and is associated with significant mortality, morbidity, and reduced quality of life. The objective of this thesis is to evaluate some therapeutic interventions and outcomes in patients with acute and chronic heart failure. In the first part, the efficacy of cardiac resynchronization therapy in patients with heart failure was explored, with more focus on patients with mild symptoms. Although cardiac resynchronization was found to reduce mortality and heart failure hospitalization and improve left ventricular ejection fraction in patients with mild symptoms, it did not improve functional outcomes, like quality of life or 6-minute walk test. In the second part of this thesis, the role of peak expiratory flow rate in assessing dyspnea improvement in patients with acute heart failure was evaluated by testing its correlation with NT-proBNP, a known prognostic marker. No significant correlation was found between short term changes in peak expiratory flow and NT-proBNP.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Department of Medicine
  • Specialization
    • Experimental Medicine
  • Supervisor / co-supervisor and their department(s)
    • Armstrong, Paul (Medicine)
    • McAlister, Finlay (Medicine)
    • Ezekowitz, Justin (Medicine)
  • Examining committee members and their departments
    • Tsuyuki, Ross (Medicine)
    • McAlister, Finlay (Medicine)
    • Armstrong, Paul (Medicine)
    • Ezekowitz, Justin (Medicine)