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- 8Heart failure
- 2Cardiac resynchronization therapy
- 1Acute coronary syndromes
- 1Acute myocardial infarction
- 1Bicarbonate transport
- 1Almajed, Nawaf S
- 1Anderson, Todd J.
- 1Becher, Harald
- 1Belenkie, Israel
- 1Brown, Brittany Fielding
- 1Brown, Paul M
Cardiac hypertrophy is maladaptive remodeling of the myocardium that often progresses to heart failure. The hypertrophic transport metabolon consists of membrane transporters implicated in hypertrophy, and substrates for these transporters are provided by the catalytic action of carbonic...
Heart failure is common, and is associated with significant mortality, morbidity, and reduced quality of life. The objective of this thesis is to evaluate some therapeutic interventions and outcomes in patients with acute and chronic heart failure. In the first part, the efficacy of cardiac...
Heart failure is associated with major changes in cardiac energy metabolism that decrease cardiac efficiency, which can reduce cardiac function. In severe heart failure there is a shift back toward a fetal heart metabolism, with a decrease in mitochondrial oxidative metabolism and increase in...
Abstract Aims: The use of telehealth for heart failure management is increasing and it is not clear from the literature whether it is more beneficial than usual care. A meta-analysis was done of published randomized controlled trials to compare telehealth management and usual physician care for...
Composite endpoints are increasingly popular outcomes in clinical trials of heart failure. Uptake has outpaced guidance on their use and little consistency is seen in their construction. We must consider how best to handle multiple outcomes statistically and clinically, ie in a way that is both...
Regulation of oxygen uptake and cardiac function in heart failure: effects of biventricular pacing and high-intensity interval exerciseDownload
Cardiac resynchronization therapy (CRT) and high-intensity interval training (HIT) have been shown to be effective for left ventricular (LV) reverse remodelling and increasing aerobic capacity in patients with heart failure (HF) and reduced ejection fraction (EF). The mechanisms underlying these...
Thompson, Richard B., Oudit, Gavin Y., Paterson, D. Ian, Becher, Harald, Kaul, Padma, Knudtson, Merril L., Dyck, Jason R.B., Lopaschuk, Gary D., Belenkie, Israel, Clark, Alexander M., Schulz, Richard, Howlett, Jonathan G., Kim, Daniel H., Anderson, Todd J., Weeks, Sarah G., Haykowsky, Mark J., McAlister, Finlay A., Ezekowitz, Justin A., Friedrich, Matthias G., Quan, Hude, Duff, Henry J., Noga, Michelle L., Kassiri, Zamaneh, Light, Peter E.
Background Nationally, symptomatic heart failure affects 1.5-2% of Canadians, incurs $3 billion in hospital costs annually and the global burden is expected to double in the next 1–2 decades. The current one-year mortality rate after diagnosis of heart failure remains high at >25%. Consequently,...
The impact of social networks on knowledge transfer in long-term care facilities: protocol for a studyDownload
Background: Social networks are theorized as significant influences in the innovation adoption and behavior change processes. Our understanding of how social networks operate within healthcare settings is limited. As a result, our ability to design optimal interventions that employ social...