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Transient deposition of particles with applications to inhaled pharmaceutical aerosols
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- Author / Creator
- Ophus, Philip S
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Most current models for the deposition of aerosol particles in the human lung
are based on a Lagrangian reference frame, which is ill-suited for modeling
transient eects. Deposition models based on an Eulerian reference frame are
much better at capturing instantaneous time-dependent eects, though they
are difficult to create. In the interest of developing such models, mathematical
techniques were used to describe the velocity elds of simple particle
ows.
Analytic expressions describing the time-dependent
ow of particles through a
curved pipe were created and implemented numerically. The numerical simulations
were used to determine which
ow regimes required the use of Eulerian
modelling for deposition prediction. -
- Subjects / Keywords
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- Graduation date
- Spring 2011
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- Type of Item
- Thesis
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- Degree
- Master of Science
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- License
- This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.