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Transient deposition of particles with applications to inhaled pharmaceutical aerosols

  • Author / Creator
    Ophus, Philip S
  • Most current models for the deposition of aerosol particles in the human lung are based on a Lagrangian reference frame, which is ill-suited for modeling transient eects. Deposition models based on an Eulerian reference frame are much better at capturing instantaneous time-dependent eects, though they are difficult to create. In the interest of developing such models, mathematical techniques were used to describe the velocity elds of simple particle ows. Analytic expressions describing the time-dependent ow of particles through a curved pipe were created and implemented numerically. The numerical simulations were used to determine which ow regimes required the use of Eulerian modelling for deposition prediction.

  • Subjects / Keywords
  • Graduation date
    2011-06
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3T39R
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Mechanical Engineering
  • Supervisor / co-supervisor and their department(s)
    • Lange, Carlos (Mechanical Engineering)
  • Examining committee members and their departments
    • Finlay, Warren (Mec. Eng.)
    • Hicks, Faye (Civil Eng.)
    • Olfert, Jason (Mec. Eng.)