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The effect of eight weeks of home based aerobic exercise training on peak exercise oxygen consumption, six-minute walk test distance, thigh muscle mass, and health related quality of life in Child Pugh class A and B cirrhosis patients

  • Author / Creator
    Kruger, Calvin P
  • Purpose: Cirrhosis patients have reduced peak aerobic power (peak VO2) that is associated with reduced survival. Supervised endurance training is an effective therapy to increase exercise tolerance in cirrhosis. The effect of home-based endurance exercise training (HET) on improving peak VO2 in cirrhosis patients has not been studied. The aim of this pilot study was to evaluate the safety and efficacy of 8 weeks of HET on peak VO2, aerobic endurance, thigh muscle thickness and circumference, and quality of life. Methods: Stable patients with Child Pugh class A and B cirrhosis were randomized to 8 weeks of HET (n=20) or usual care (controls, n=20). The HET group performed moderate-high intensity cycle exercise 3 days per week. An exercise therapist supervised a HET session biweekly. Paired t-test was used for within group comparisons and ANCOVA was used to perform between group comparisons due to baseline differences and small sample size. Results: The cohort (n=40) was 58% male (mean age of 57 ± 8 years), and 70% had Child Pugh class A cirrhosis. The between group VO2 difference trended to significance (1.7 (-0.33 to 3.7), p=0.09) and the between group 6-minute walk test significantly increased (33.7 (5.1 to 62.4), p=0.02). Within groups, the HET group had a significant increase in peak VO2 from baseline (17.3 ± 4.5 to 19.0 ± 6.4 mL/kg/min, p=0.03). There was a significant increase in the thigh circumference (50.6 ± 5.8 to 52.4 ± 6.6 cm, p=0.02) and thigh muscle thickness (1.25 ± 0.40 to 1.31 ± 0.38 cm/m2, p=0.05). There were no significant changes in quality of life and no there were no adverse events reported. Conclusions: Eight weeks of HET shows promise as a safe and effective intervention to improve fitness outcomes in patients with liver cirrhosis.

  • Subjects / Keywords
  • Graduation date
    2017-11:Fall 2017
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R30C4SZ83
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Faculty of Rehabilitation Medicine
  • Specialization
    • Rehabilitation Science
  • Supervisor / co-supervisor and their department(s)
    • McNeely, Margaret (Rehabilitation Medicine)
    • Tandon, Puneeta (Medicine)
  • Examining committee members and their departments
    • Tandon, Puneeta (Medicine)
    • Pituskin, Edith (Nursing)
    • McNeely, Margaret (Rehabilitation Medicine)
    • Haykowsky, Mark (Nursing, University of Texas at Arlington)