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The na+/H+ exchanger in metastasis
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- Author(s) / Creator(s)
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Introduction: Triple-negative breast cancer, in which cells lack the expression of estrogen, progesterone, and human epidermal growth factor 2 receptors, is a clinical subtype of breast cancer commonly associated with poor prognosis. It tends to be aggressively metastatic with a high recurrence rate and little response to standard chemotherapy [1]. Mounting evidence suggests that one triggering event in oncogenic transformation is an imbalance in acid-base homeostasis, with an increase in intracellular pH and acidification of the extracellular tumor microenvironment [2].
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- Date created
- 2016-01-01
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- Subjects / Keywords
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- Type of Item
- Article (Published)
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- License
- Attribution 4.0 International