SearchSkip to Search Results
- 4Amith, Schammim Ray
- 4Fliegel, Larry
- 2Baksh, Shairaz
- 2Wilkinson, Jodi Marie
- 1Boukouris, Aristeidis
- 1Fong, Sunny
A Reversible Metabolic Stress-Sensitive Regulation of Collapsin Response Mediator Protein 2A Orchestrates Cytoskeletal Remodeling and EMT, Increasing Metastatic Potential in CancerDownload
Cancer represents the second leading cause of death globally only after heart disease and is responsible for about 10 million deaths per year with a significant economic impact (WHO facts). Moreover, its prevalence is projected to increase over the following decades. Among all cancers, breast,...
Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitroDownload
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal expression of their ion transporters and related...
Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cellsDownload
In triple-negative breast cancer (TNBC), the high recurrence rate, increased invasion and aggressive metastatic formation dictate patient survival. We previously demonstrated a critical role for the Na+/H+ exchanger isoform 1 (NHE1) in controlling metastasis of triple-negative cells. Here, we...
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and...
Increased expression of autotaxin has been shown to promote metastasis formation and cancer proliferation. These actions could be related to the catalytic activity of autotaxin which converts lysophosphatidylcholine into lysophosphatidate extracellularly or non-catalytic functions...
Metastasis is the leading cause of cancer-related deaths, yet there are no therapies that directly target this process. To identify potential therapeutic targets of metastatic dissemination, we recently completed the first whole human genome shRNA screen using a novel avian embryo intravital...
The na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cellsDownload
Dysregulation of Na+/H+ exchanger isoform one (NHE1) activity is a hallmark of cells undergoing tumorigenesis and metastasis, the leading cause of patient mortality. The acidic tumor microenvironment is thought to facilitate the development of resistance to chemotherapy drugs and to promote...
Introduction: Triple-negative breast cancer, in which cells lack the expression of estrogen, progesterone, and human epidermal growth factor 2 receptors, is a clinical subtype of breast cancer commonly associated with poor prognosis. It tends to be aggressively metastatic with a high recurrence...