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Permanent link (DOI): https://doi.org/10.7939/R35D1X

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Urinary Metabolomic Signature of Pancreatic Ductal Adenocarcinoma Open Access

Descriptions

Other title
Subject/Keyword
Metabolomics
Screening
Pancreatic Ductal Adenocarcinoma
Urine
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Davis, Vanessa W
Supervisor and department
Eurich, Dean (Public Health Sciences)
Sawer, Michael B (Department of Medical Oncology)
Schiller, Daniel E (Department of Surgery)
Examining committee member and department
Schiller, Daniel E (Department of Surgery)
Bigam, David (Department of Surgery)
Eurich, Dean (Public Health Sciences)
Sawyer, Michael B (Department of Medical Oncology)
Department
School Public Health Sciences
Specialization

Date accepted
2012-05-25T09:14:29Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Pancreatic cancer is a leading cause of cancer-related death, due to its aggressive biology, lack of tools for early diagnosis and screening, advanced presentation and resistance to adjuvant therapy. Metabolomics, the newest of the “omics” sciences, may offer the potential for non-invasive screening of early tumor associated perturbations in cellular metabolism. We applied metabolomic techniques as a potential discriminating tool in the diagnosis of early stage and locally advanced pancreatic cancer. Urinary nuclear magnetic resonance spectroscopic analysis of pancreatic ductal adenocarcinoma was associated with a distinct metabolomics signature, was detectable in both early stage and locally advanced disease when compared with healthy, age and gender matched controls and was extinguished following complete, R0 surgical resection. These preliminary results suggest that metabolomics approaches may facilitate discovery of novel biomarkers capable of early disease detection.
Language
English
DOI
doi:10.7939/R35D1X
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Davis VW, Bathe OF, Schiller DE, Slupsky CM and MB Sawyer. Metabolomics and Surgical Oncology: Potential Role for Small Molecule Biomarkers. Journal of Surgical Oncology 2011;103: 451-459

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File format: pdf (Portable Document Format)
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File size: 9394447
Last modified: 2015:10:12 20:34:29-06:00
Filename: Davis_Vanessa Fall 2012.pdf
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Status message: File header gives version as 1.4, but catalog dictionary gives version as 1.3
File title: Microsoft Word - Thesis All Sections May 23.docx
File author: Vanessa Davis
Page count: 145
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