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Permanent link (DOI): https://doi.org/10.7939/R36M66

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Characterisation of the sleep-related slow oscillation in the neocortical - entorhinal - hippocampal bidirectional circuit Open Access

Descriptions

Other title
Subject/Keyword
urethane
slow wave sleep
hippocampus
memory
entorhinal cortex
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Wolansky, Trisha
Supervisor and department
Dr. Clayton T. Dickson (Psychology, Physiology, and Centre for Neuroscience)
Examining committee member and department
Dr. Kelvin E. Jones (Physical Education and Centre for Neuroscience)
Dr. C. Andrew Chapman (Concordia University, Montréal, Québec, Canada)
Dr. John J. Greer (Physiology and Centre for Neuroscience)
Dr. Christopher B. Sturdy (Psychology and Centre for Neuroscience)
Dr. Jeremy B. Caplan (Psychology and Centre for Neuroscience)
Department
Centre for Neuroscience
Specialization

Date accepted
2009-10-07T19:01:13Z
Graduation date
2009-11
Degree
Doctor of Philosophy
Degree level
Doctoral
Abstract
Our ability to recall information and events is astounding and dependent on the medial temporal lobe (MTL) memory system. The synaptic interconnections between the neocortex (nCTX), entorhinal cortex (EC), and hippocampus (HPC) are the anatomical basis of this memory system. The electrophysiological basis of memory formation in this system is largely unknown, but the activity patterns that occur during slow wave sleep (SWS) are thought to play an important role. One prominent activity pattern that occurs during SWS is the slow oscillation (SO). It is a large-amplitude rhythm of ~1Hz that was first described in the nCTX and only occurs during SWS and deep anaesthesia. Using the urethane-anaesthetised rat, I provide the first description of the SO in the HPC in Chapter 2. I found that the SO in the HPC was dynamically coordinated with that in the nCTX. Because the EC is the anatomical interface between the nCTX and HPC, I hypothesised that it could be responsible for this coordination. Chapter 3 characterises the SO in the EC and its coordination with both the nCTX and HPC. My results suggested that the synaptic interconnections between the nCTX and HPC via the EC were not solely responsible for SO coordination across these structures. Another possibility is that SO coordination across the nCTX, EC, and HPC occurs via the nucleus reuniens thalami (NReu). In Chapter 4, I delivered trains of electrical stimulation to the frontal cortex (fCTX) to enhance the SO in the nCTX and assess any effect in the HPC. In addition, I delivered the same stimulation trains directly to the medial prefrontal cortex (mpfCTX) and NReu. I found that repeated stimulation in each structure entrained the hippocampal SO. I also found that repeated stimulation of the fCTX and mpfCTX enhanced SO coordination across the nCTX and HPC, but repeated stimulation of the NReu did not. My results suggested that SO coordination across the nCTX and HPC occurs via both the EC and NReu. Understanding the coordination of SO activity across these structures will provide insight to the electrophysiological basis of the MTL memory system and the role of SWS in its function.
Language
English
DOI
doi:10.7939/R36M66
Rights
License granted by Trisha Wolansky (trish.w@shaw.ca) on 2009-10-07T15:49:11Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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