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- 1Arvanitidis, Anastasia P
- 1Connor, Steven
- 1Engin, Elif
- 1Greenberg, Anastasia
- 1Huang, Yushan Yu Xiang
- 1Kantor, Chase M
Characterisation of the sleep-related slow oscillation in the neocortical - entorhinal - hippocampal bidirectional circuitDownload
Our ability to recall information and events is astounding and dependent on the medial temporal lobe (MTL) memory system. The synaptic interconnections between the neocortex (nCTX), entorhinal cortex (EC), and hippocampus (HPC) are the anatomical basis of this memory system. The...
Hippocampal activity is characterized by two state-dependent, mutually exclusive large-amplitude oscillations: theta (3-12 Hz) and the hippocampal slow oscillation (SO; ~1 Hz). These two rhythms have been implicated in different stages of memory processing. Theta occurs during awake exploratory...
Oscillations are a fundamental principle of neural operation, organized into a hierarchy of frequency bands with the dominant rhythm alternating within and across behavioral states. During states of sleep and anesthesia, brain activity in forebrain regions displays two major distinct activity...
The hippocampus is a brain structure responsible for memory, learning, and the stress response; it is also used as a model for major depressive disorder (MDD) in preclinical studies. Preclinical models have shown that the hippocampal subfields are differentially affected by chronic stress....
Modulation of Spontaneous Neural Network Bursting in Newborn Rat Brain Slices by Extracellular Calcium, Methylxanthines, and OpioidsDownload
Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...
NOREPINEPHRINE-MEDIATED SYNAPTIC PLASTICITY: A NOVEL SIGNALING DIALOGUE BETWEEN RECEPTORS AND NUCLEUSDownload
Norepinephrine (NE) helps in the consolidation and retention of memories of emotionally charged events. However, the pathway from membrane receptors to nucleus in noradrenergic signaling in the brain is not completely understood. The cyclic AMP-PKA pathway is one of the most studied signaling...
The ability of synapses to undergo lasting changes in synaptic strength is considered the primary cellular mechanism for associative memory formation in the mammalian brain. Synapses in the hippocampus, a brain structure required for new memory genesis, exhibit a remarkable capacity for...
The acquisition of a behavioural response (learning) and the later retrieval of this response (memory) are separated by an endogenous biological process which consolidates the temporary neural changes initiated by training. Intracerebral infusions of stimulants to the hippocampus potentiate this...
Despite considerable research progress towards characterizing the neurobiology of anxiety, the focus on putative behavioral markers and the absence of a common behavioural/neurobiological signature for the different classes of anxiolytic drugs have potentially slowed research into the neural...
Approximately 50 million people worldwide suffer from epilepsy, a chronic neurological disorder characterized by recurrent seizures. While most patients with epilepsy will respond to anticonvulsant medications, approximately one third are found to have drug resistant epilepsy. Mesial temporal...