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Permanent link (DOI): https://doi.org/10.7939/R3PK07F6J

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Increased rate of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats Open Access

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Author or creator
Luiken, Joost J. F. P.
Arumugam, Yoga
Dyck, David J.
Bell, Rhonda C.
Pelsers, Maurice M. L.
Turcotte, Lorraine P.
Tandon, Narendra N.
Glatz, Jan F. C.
Bonen, Arend
Additional contributors
Subject/Keyword
Bioenergetics
Metabolism
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Giant vesicles were used to study the rates of uptake of long-chain fatty acids by heart, skeletal muscle, and adipose tissue of obese and lean Zucker rats. With obesity there was an increase in vesicular fatty acid uptake of 1.8-fold in heart, muscle and adipose tissue. In some tissues only fatty acid translocase (FAT) mRNA (heart, +37%; adipose, +80%) and fatty acid-binding protein (FABPpm) mRNA (heart, +148%; adipose, +196%) were increased. At the protein level FABPpm expression was not changed in any tissues except muscle (+14%), and FAT/CD36 protein content was altered slightly in adipose tissue (+26%). In marked contrast, the plasma membrane FAT/CD36 protein was increased in heart (+60%), muscle (+80%), and adipose tissue (+50%). The plasma membrane FABPpm was altered only in heart (+50%) and adipose tissues (+70%). Thus, in obesity, alterations in fatty acid transport in metabolically important tissues are not associated with changes in fatty acid transporter mRNAs or altered fatty acid transport protein expression but with their increased abundance at the plasma membrane. We speculate that in obesity fatty acid transporters are relocated from an intracellular pool to the plasma membrane in heart, muscle, and adipose tissues.
Date created
2001
DOI
doi:10.7939/R3PK07F6J
License information
© 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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Citation for previous publication
Luiken, J. J. F., Arumugam, Y., Dyck, D. J., Bell, R. C., Pelsers, M. M. L., Turcotte, L. P., Tandon, N. N., Glatz, J. F. C., & Bonen, A. (2001). Increased rate of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats. Journal of Biological Chemistry, 276(44), 40567-40573.  http://dx.doi.org/10.1074/jbc.M100052200

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