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Permanent link (DOI): https://doi.org/10.7939/R3T39R

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Transient deposition of particles with applications to inhaled pharmaceutical aerosols Open Access

Descriptions

Other title
Subject/Keyword
particle
transient
aerosol
deposition
pharmaceutical
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Ophus, Philip S
Supervisor and department
Lange, Carlos (Mechanical Engineering)
Examining committee member and department
Hicks, Faye (Civil Eng.)
Finlay, Warren (Mec. Eng.)
Olfert, Jason (Mec. Eng.)
Department
Department of Mechanical Engineering
Specialization

Date accepted
2011-02-01T23:46:32Z
Graduation date
2011-06
Degree
Master of Science
Degree level
Master's
Abstract
Most current models for the deposition of aerosol particles in the human lung are based on a Lagrangian reference frame, which is ill-suited for modeling transient eects. Deposition models based on an Eulerian reference frame are much better at capturing instantaneous time-dependent eects, though they are difficult to create. In the interest of developing such models, mathematical techniques were used to describe the velocity elds of simple particle ows. Analytic expressions describing the time-dependent ow of particles through a curved pipe were created and implemented numerically. The numerical simulations were used to determine which ow regimes required the use of Eulerian modelling for deposition prediction.
Language
English
DOI
doi:10.7939/R3T39R
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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