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Permanent link (DOI): https://doi.org/10.7939/R3V913

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Influence of dietary fat intake on acute changes in postprandial lipid and lipoprotein expression in children and adolescents with nonalcoholic fatty liver disease (NAFLD) Open Access

Descriptions

Other title
Subject/Keyword
Body composition
Insulin resistance
NAFLD
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Rodriguez Dimitrescu, Carla
Supervisor and department
Mager, Diana (Agricultural Food and Nutritional Science)
Examining committee member and department
Gilmour, Susan (Pediatrics)
Suh, Miyoung (Human Nutritional Sciences)
Chan, Catherine (Agricultural, Food and Nutritional Science)
Bell, Rhonda (Agricultural, Food and Nutritional Science)
Mazurak, Vera (Agricultural, Food and Nutritional Science)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization
Nutrition and Metabolism
Date accepted
2012-09-28T13:11:23Z
Graduation date
2012-09
Degree
Doctor of Philosophy
Degree level
Doctoral
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that typically occurs in obese children and adolescents with hyperinsulinemia/insulin resistance and dyslipidemia. While treatment is aimed at lifestyle modification (diet and physical activity), very little is known regarding the contribution of diet to underlying metabolic processes leading to hepatic damage and how modification of meal patterning might contribute to improved patient outcomes. We hypothesized that children and adolescents with biopsy proven NAFLD will be characterized by different body fat distribution, prolonged postprandial hyperinsulinemia, lipemia and altered lipoprotein and inflammatory marker expression when compared to obese and lean healthy children and adolescents after consumption of two different high saturated fat meal challenges (with varying long chain polyunsaturated fat: 0% LCPUFA vs 1.5% LCPUFA). Children and adolescents with NAFLD had higher fat localized to the visceral region compared to the other groups. Higher (p>0.05) trunk to extremity ratio and waist to hip ratio was observed in children with NAFLD. Fasting and postprandial insulin were higher (p<0.05) in the NAFLD when compared to lean and obese controls. NEFA postprandial clearance in NAFLD population was significantly lower when compared to obese and lean controls. NAFLD subjects were characterized by higher (p<0.05) fasting Apo B-100 and C-III as well as higher postprandial Apo B-48; all suggestive of differences in fat balance across the liver following a meal. Acute changes in LCPUFA intake in a high saturated fat meal resulted in significant lowering of iAUC for NEFA in the NAFLD group and significant increased postprandial changes in Apo C-III, but did not evoke any other major postprandial changes in lipoprotein expression. In conclusion our study suggests that children and adolescents with NAFLD exhibit delayed postprandial lipid and lipoprotein expression in comparison to lean controls. Acute changes in LCPUFA content in a high saturated meal, reflective of the typical amounts present in a fast food meal, evoke small postprandial changes in children and adolescents with NAFLD. Whether an improvement in postprandial lipid clearance can be obtained through a higher LCPUFA dose or whether responses are mainly determined by the chronic intake should be further investigated
Language
English
DOI
doi:10.7939/R3V913
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Mager D, Rodriguez Dimitrescu C, Yap J, Ball G, et al. Anthropometric measures of visceral and subcutaneous fat are important in the determination of metabolic dysregulation in boys and girls at risk for nonalcoholic fatty liver disease. Nutrition on clinical practice. 2012. Recently accepted.

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