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Skip to Search Results- 1Ab Aziz, Nusaibah
- 1Al-Karaghouli, Mustafa Thaier Salman
- 1Berg, Emily
- 1Hsu, Mu Hao
- 1Lee, Megan CMH
- 1Rodriguez Dimitrescu, Carla
- 1Chan, Catherine B (Physiology; Food & Nutrition Science)
- 1Clemente-Casares, Xavier (Medical Microbiology and Immunology)
- 1Damaraju, Sambasivarao (Laboratory Medicine and Pathology)
- 1Jacobs, Rene (Agricultural, Food and Nutritional Science)
- 1Jacobs, Rene (Agriculture, Food and Nutritional Science)
- 1Juan Gonzalez-Abraldes (Department of medicine)
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Identification and Validation of a Common Molecular Signature of Progressive Fibrosis in Human Livers
DownloadSpring 2020
Over 25% of the world population suffer from chronic liver disease. Most common causes are long-term viral infections, alcohol abuse, and non-alcoholic fatty liver disease (NAFLD) associated with obesity, diabetes or hyperlipidemia. Chronic liver disease due to any cause is characterized by...
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Spring 2021
Al-Karaghouli, Mustafa Thaier Salman
Background and Rationale The degree of fibrosis in nonalcoholic fatty liver disease (NAFLD) determines the risk of liver complications. Non-invasive tests (NITs) such as FIB-4, NFS and Hepamet, have been proposed to triage patients in primary care (PC) for further assessment due to their high...
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Impacts of non- and whole-fat milk supplementation on metabolic dysfunction-associated steatotic liver disease (MASLD) in C57BL/6 mice
DownloadFall 2024
The pathophysiology behind metabolic dysfunction-associated steatotic liver disease (MASLD) and mechanisms underlying the progression of the disease are highly complex, complicating treatment options, leaving diet and weight loss as the standard of care. Functional foods can mitigate MASLD...
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Influence of dietary fat intake on acute changes in postprandial lipid and lipoprotein expression in children and adolescents with nonalcoholic fatty liver disease (NAFLD)
DownloadFall 2012
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that typically occurs in obese children and adolescents with hyperinsulinemia/insulin resistance and dyslipidemia. While treatment is aimed at lifestyle modification (diet and physical activity), very little is known regarding...
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Insights into the Role of Phosphatidylethanolamine N-methyltransferase and the PC:PE Ratio in Liver Function
DownloadSpring 2019
PEMT is quantitatively important in the liver and is responsible for approximately 30% of hepatic PC synthesis, with the remaining 70% synthesized by the CDP-choline pathway. HFD-fed Pemt-/- mice and LPcyt1a-/- mice both develop NAFLD associated with reduced VLDL secretion and a reduced hepatic...
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Role of Betaine Homocysteine Methyltransferase in Regulating Lipid Metabolism in McArdle RH7777 Cells
DownloadFall 2013
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. It is a clinical pathological state characterized by the accumulation of triacylglycerol (TG) in hepatocytes. It can progress to non-alcoholic steatohepatitis (NASH) and in some cases to fibrosis...
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The role of obesity and insulin resistance in modulating immune cell function in cancer and liver disease
DownloadFall 2023
Obesity and associated insulin resistance (IR) represent a significant global health burden, and predispose individuals to develop various diseases, including cancer and liver diseases. Heightened inflammation during obesity can on the one hand exacerbate liver inflammation, while on the other,...