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Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: A systematic review Open Access
- Other title
opioid induced constipation
- Type of item
- Degree grantor
University of Alberta
- Author or creator
Kerridge, Teresa A.
- Supervisor and department
Hunter, Kathleen (Nursing)
- Examining committee member and department
Hunter, Kathleen (Nursing)
Cummings, Greta (Nursing)
Lazarescu, Adriana (Gastroenterology)
Faculty of Nursing
- Date accepted
- Graduation date
Master of Nursing
- Degree level
Opioid-induced constipation (OIC) is an unpleasant and ubiquitous side effect of opioid treatment. Ineffective treatment of OIC can result in decreased adherence to opioid therapy, decreased quality of life, and increased morbidity and mortality. The constipating effects of opioids result from their inhibitory effects on μ, κ, and δ receptors in the gastrointestinal tract causing hard and dry stools, prolonged transit time, decreased gastric secretions, and ineffective colonic emptying. Current treatment of OIC occurs by trial and error; little evidence exists to guide practice. Docusate sodium, sennosides, and lactulose are common drugs used in constipation prevention and management in OIC. This systematic review investigates whether PEG is superior to doscusate sodium, sennosides, and/or lactulose in the treatment of OIC. Despite extensive search strategies, no studies met our inclusion criteria. Consequently, insufficient evidence exists to address this clinical question. Further research is required and high-powered, well-designed clinical trials are economically feasible.
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File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 780451
Last modified: 2015:10:12 14:37:25-06:00
Original checksum: 8c740a6011dc44c83dc0e5f772d51b2e
Well formed: true
Status message: File header gives version as 1.4, but catalog dictionary gives version as 1.3
File author: Teresa Kerridge
Page count: 77