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Theses and Dissertations
This collection contains theses and dissertations of graduate students of the University of Alberta. The collection contains a very large number of theses electronically available that were granted from 1947 to 2009, 90% of theses granted from 2009-2014, and 100% of theses granted from April 2014 to the present (as long as the theses are not under temporary embargo by agreement with the Faculty of Graduate and Postdoctoral Studies). IMPORTANT NOTE: To conduct a comprehensive search of all UofA theses granted and in University of Alberta Libraries collections, search the library catalogue at www.library.ualberta.ca - you may search by Author, Title, Keyword, or search by Department.
To retrieve all theses and dissertations associated with a specific department from the library catalogue, choose 'Advanced' and keyword search "university of alberta dept of english" OR "university of alberta department of english" (for example). Past graduates who wish to have their thesis or dissertation added to this collection can contact us at erahelp@ualberta.ca.
Items in this Collection
- 4Lovastatin
- 2Polyketides
- 1Acyl carrier protein
- 1Biological Diels-Alder reaction
- 1Biosynthesis
- 1Chaetoglobosin
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Biochemical investigations of two polyketide synthase subclasses – highly reducing/non-reducing pairs, and polyketide synthase non-ribosomal peptide synthetases.
DownloadSpring 2016
Cladosporin is a polyketide metabolite that is biosynthesized by a highly reducing (HR)/non-reducing (NR) polyketide synthase (PKS) pair, wherein they catalyse head-totail condensation of acetyl and malonyl CoA units with subsequent β-keto modification. Cladosporin has recently been reported as a...
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Inhibition Studies of DapL Enzymes Orthologs and Synthesis of Proposed Biosynthetic Intermediates of Tabtoxin and Synthesis of a Hexaketide as a Standard for Lovastatin Studies
DownloadFall 2017
The enzyme LL-diaminopimelate aminotransferase (DapL) catalyzes the transformation of L-THDP to LL-DAP during the biosynthesis of lysine in plants, alga, and in some pathogenic bacteria like Leptospira interrogans and Verrucomicrobium spinosum. Because the biosynthesis of lysine is absent in...
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Investigation of the biosynthesis of lovastatin and cytochalasin E, two fungal polyketides assembled by iterative PKS-NRPS enzymes
DownloadFall 2015
Cytochalasin E and lovastatin are two fungal polyketides that have seen extensive use as an angiogenesis inhibitor and as a cholesterol-lowering agent, respectively. These structurally divergent compounds are synthesized by polymerization of acetate units with concomitant functionalization by two...
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Investigations of Fungal Highly Reducing Polyketide Synthases: The Biosyntheses of Lovastatin and Hypothemycin
DownloadFall 2017
Fungal highly reducing polyketide synthases (HR-PKSs) are large, multi-domain enzymes central to the biosynthesis of fungal polyketides. They assemble complex secondary metabolites, called polyketides, through the condensation of two-carbon acetate units and tailoring of the functional groups at...