Journal Articles (Biochemistry)
Items in this Collection
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2002-01-01
Li, Xiuju J., Misik, Angelika J., Rieder, Carmen V., Solaro, R. John, Lowen, Anice, Fliegel, Larry
In this paper we examine the role of thyroid hormone in regulating expression of the Na+/H+ exchanger. Thyroid hormone has been reported to regulate the activity of the Na+/H+ exchanger messenger RNA in some cell types. Treatment of cardiac myocytes with 3,5′,3′-triiodothyronine results in an...
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Transmembrane segment XI of the na+/H+ antiporter of S. pombe is a critical part of the ion translocation pore
Download2017-01-01
Dutta, Debajyoti, Shin, Kyungsoo, Rainey, Jan K., Fliegel, Larry
The Na+/H+ exchanger of the plasma membrane of S. pombe (SpNHE1) removes intracellular sodium in exchange for an extracellular proton. We examined the structure and functional role of amino acids 360–393 of putative transmembrane (TM) segment XI of SpNHE1. Structural analysis suggested that it...
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Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization
Download2001-01-01
Khaled, Annette R., Moor, Andrea N., Li, Aiqun Q., Kim, Kyungjae, Ferris, Douglas K., Muegge, Kathrin, Fisher, Robert J., Fliegel, Larry, Durum, Scott K.
Trophic factor withdrawal induces cell death by mechanisms that are incompletely understood. Previously we reported that withdrawal of interleukin-7 (IL-7) or IL-3 produced a rapid intracellular alkalinization, disrupting mitochondrial metabolism and activating the death protein Bax. We now...