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Skip to Search Results- 1Durum, Scott K.
- 1Ferris, Douglas K.
- 1Fisher, Robert J.
- 1Fliegel, Larry
- 1Khaled, Annette R.
- 1Kim, Kyungjae
- 1Cell Growth And Development
- 1Cultured-Cells
- 1Cytokine Receptors
- 1Flow-Cytometry
- 1Growth-Factors
- 1In-Vivo
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Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization
Download2001-01-01
Khaled, Annette R., Moor, Andrea N., Li, Aiqun Q., Kim, Kyungjae, Ferris, Douglas K., Muegge, Kathrin, Fisher, Robert J., Fliegel, Larry, Durum, Scott K.
Trophic factor withdrawal induces cell death by mechanisms that are incompletely understood. Previously we reported that withdrawal of interleukin-7 (IL-7) or IL-3 produced a rapid intracellular alkalinization, disrupting mitochondrial metabolism and activating the death protein Bax. We now...