Journal Articles (Agricultural, Food and Nutritional Science)
Items in this Collection
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Gene-expression profiling of calves 6 and 9 months after inoculation with Mycobacterium avium subspecies paratuberculosis
Download2014
David, Joel, De Buck, Jeroen, Barkema, Herman W., Guan, Leluo
Early detection of Johne's disease (JD) caused by Mycobacterium avium subspecies paratuberculosis (MAP) is essential to reduce transmission; consequently, new diagnostic techniques and approaches to detect MAP or markers of early MAP infection are being explored. The objective was to identify...
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2011
Bergen, Werner G., Fernyhough, Melinda E., Hausman, Gary J., Dodson, Mike V., Du, Min, Mir, Priya S., Guan, Leluo, Jiang, Zhihua
Obesity and metabolic syndromes are examples whereby excess energy consumption and energy flux disruptions are causative agents of increased fatness. Because other, as yet elucidated, cellular factors may be involved and because potential treatments of these metabolic problems involve systemic...
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Bacterial response to siderophore and quorum-sensing chemical signals in the seawater microbial community
Download2001
Background Oceans are iron-deficient and nutrient-poor environments. These conditions impart limitations on our understanding of and our ability to identify microorganisms from the marine environment. However, less of knowledge on the influence of siderophores and N-acyl homoserinelactone as...
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2009
Grant, Jason, Stothard, Paul, Moore, Stephen S., Guan, Leluo, Jin, Weiwu
Background MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules which regulate gene expression by fully or partially binding to their complementary sequences in mRNAs or promoters. A large number of miRNAs and their expression patterns have been reported in human, mouse and rat....
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The gut microbiome and its potential role in the development and function of newborn calf gastrointestinal tract
Download2015
Grebiel, Philip J., Malmuthuge, Nilusha, Guan, Leluo
A diverse microbial population colonizes the sterile mammalian gastrointestinal tract during and after the birth. There is increasing evidence that this complex microbiome plays a crucial role in the development of the mucosal immune system and influences newborn health. Microbial colonization is...
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Reducing GHG emissions through genetic improvement for feed efficiency: Effects on economically important traits and enteric methane production
Download2013
Baron, Vern S., Ominski, Kim H., Guan, Leluo, Basarab, John A., Beauchemin, Karen A., Miller, Stephen P.
Genetic selection for residual feed intake (RFI) is an indirect approach for reducing enteric methane (CH4) emissions in beef and dairy cattle. RFI is moderately heritable (0.26 to 0.43), moderately repeatable across diets (0.33 to 0.67) and independent of body size and production, and when...
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Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life
Download2014
Liang, Guanxiang, Bao, Hua, Guan, Leluo, Griebel, Philip J., Stothard, Paul, McFadden, Thomas B., Malmuthuge, Nilusha
This study aimed to investigate the potential regulatory role of miRNAs in the development of gastrointestinal tract (GIT) during the early life of dairy calves. Rumen and small intestinal (mid-jejunum and ileum) tissue samples were collected from newborn (30 min after birth; n = 3), 7-day-old...
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Microarray analysis in caudal medulla of cattle orally challenged with bovine spongiform encephalopathy
Download2011
Williams, John L., Moore, Stephen S., Almeida, Luciane M., Basu, Urmila, Guan, Leluo
Bovine spongiform encephalopathy (BSE) is a fatal disorder in cattle characterized by progressive neurodegeneration of the central nervous system. We investigated the molecular mechanisms involved in neurodegeneration during prion infection through the identification of genes that are...
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Xylo-oligosaccharides and virginiamycin differentially modulate gut microbial composition in chickens
Download2015
Zhao, Xin, Pourabedin, Mohsen, Guan, Leluo
Background The emergence and spread of antibiotic resistance in pathogens have led to a restriction on the use of antibiotic growth promoters (AGPs) in animal feed in some countries. The potential negative after-effects of a ban on AGPs could be mitigated by improving animal intestinal health...
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Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureus bacteria reveals pathogen directed microRNA expression profiles
Download2014
Zhao, Xin, Liang, Guanxiang, Jin, Weiwu, Guan, Leluo, Beaudoin, Frédéric, Ibeagha-Awemu, Eveline M.
Background MicroRNAs (miRNAs) can post-transcriptionally regulate gene expression and have been shown to be critical regulators to the fine-tuning of epithelial immune responses. However, the role of miRNAs in bovine responses to E. coli and S. aureus, two mastitis causing pathogens, is not well...