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Medical Oncology
The Division of Medical Oncology focuses on systemic therapy for patients with cancer. We are actively involved in improving the outcome of patients through research and quality improvement programs. Members of the Division are responsible for education and training of undergraduate and postgraduate students and the continuous professional development of practitioners.
Items in this Collection
- 2Tuszynski, Jack A.
- 1 Dumonte, Charles
- 1 Preto, Jordane
- 1 Spasevska, Ivana
- 1 Tuszynski, Jack A
- 1 Winter, Philip
- 4Oncology, Department of
- 4Oncology, Department of/Medical Oncology
- 1Rehabilitation Medicine, Faculty of
- 1Rehabilitation Medicine, Faculty of/Physical Therapy
- 1Surgery, Department of
- 1Surgery, Department of/General Surgery
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2010-01-01
McNeely, Margaret L., Campbell, Kristin, Ospina, Maria, Rowe, Brian H., Dabbs, Kelly, Klassen, Terry P., Mackey, John, Courneya, Kerry S.
Background Upper-limb dysfunction is a commonly reported side effect of treatment for breast cancer and may include decreased shoulder range of motion (the range through which a joint can be moved) (ROM) and strength, pain and lymphedema. Objectives To review randomized controlled trials (RCTs)...
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Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Download2017-08-02
Ayoub, Ahmed T , Dumonte, Charles, Wong, Gane K-S, Preto, Jordane, Tuszynski, Jack A, Spasevska, Ivana, Winter, Philip
Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and...
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Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Download2017-08-02
Spasevska, Ivana , Wong, Gane K.-S. , Preto, Jordane , Winter, Philip , Dumontet , Charles , Ayoub, Ahmed T. , Tuszynski, Jack A.
Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and...
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2016-12-09
Winter, Philip, Wang, Xumin, Mackey, John R. , Lee, John C. , Wong, Gane Ka-Shu, Ghosh, Sunita, Patterson, Jordan, Zhang, Hangxiao, Wang, Weiwei, Tuszynski, Jack A. , Katsetos, Christos D., Graham, Kathryn, Luduena, Richard F.
Tubulin is the target for very widely used anti-tumor drugs, including Vinca alkaloids, taxanes, and epothilones, which are an important component of chemotherapy in breast cancer and other malignancies. Paclitaxel and other tubulin-targeting drugs bind to the β subunit of tubulin, which is a...