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Spring 2017
Introduction: Genome wide association studies (GWAS) have been widely used in recent years to identify the new information on genetic variants which are associated with complex trait in many diseases. Advances in identifying the Single nucleotide polymorphisms (SNPs) facilitate the study of...
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Updating Local Birth Weight Percentiles and Statistical Methods Motivated by Challenges in Analysis of Microbiome Studies
DownloadFall 2022
This dissertation contains two main parts. In part one, I updated the current reference for sex-specific birth weight percentiles by gestational age, overall, and for specific ethnic groups, based on data from all singleton live-birth deliveries from 2005 to 2014 in Alberta, Canada. Crude and...
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Effect of environmental exposure on infant gut microbiota composition and diversity in the Canadian Healthy Infant Longitudinal Development (CHILD) national birth cohort
DownloadFall 2016
Background: The development of infant gut microbiota plays a crucial role in immune system development, and infant gut microbiota dysbiosis has been linked to asthma and allergic disease. Studies have shown that Bacteroidetes phylum was less abundant in the guts of allergic children. Although...
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Fall 2018
Human genomic data are being generated at an increasing rate owing to the advancement of high-throughput technology. Wider availability of genomics, transcriptomics, proteomics and metabolomics data motivated complex study questions with the intention to gain higher degree of understanding of...