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- 8Lowary, Todd (Chemistry)
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- 1Lucy, Charles (Chemistry)
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- 1Byers, Brock W
- 1Dunbar, Christine R
- 2Interrupted Nazarov reaction
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Synthesis of Lipopolysaccharide O-antigens from Klebsiella pneumoniae Serotype O2a as Molecular Probes for Biosynthetic Studies
DownloadFall 2018
Many Gram-negative bacteria are pathogenic organisms that can cause disease and death. As antibiotic resistance and nosocomial disease occurrences both increase, these infections are becoming more problematic. These issues can be partially attributed to lipopolysaccharide (LPS), which is a major...
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Synthesis of Medium-Sized Oxygen and Nitrogen Heterocycles via Stevens Rearrangement of Sulfonium Ylides and Formal Synthesis of (+)-Laurencin
DownloadFall 2017
Medium-sized cyclic ether and amine motifs often constitute the framework of a variety of natural products with interesting biological activities. As a result, the construction of these heterocycles is an important subject in organic synthesis, which has triggered the development of many...
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Synthesis of fragments of a polysaccharide from Nocardia nova for structural and biological studies
DownloadSpring 2020
Nocardia are gram-positive bacteria. Nocardia nova is one of the Nocardia species and can cause serious disease, particularly in immunocompromised patients. Rapid diagnosis of N. nova can be lifesaving. The cell wall of N. nova contains an unusual glucose-modified arabinogalactan polysaccharide...
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Synthetic Studies Towards (+)-Dactylol Utilizing an Oxonium Ylide Rearrangement and Related Studies.
DownloadFall 2011
Dactylol is a structurally interesting sesquiterpene natural product. One of its key structural features is an the eight-membered ring. The challenges of synthesizing an eight membered ring are discussed in Chapter 1. In addition, various methods for generating an eight-membered ring are...
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The [1,2]-Stevens Rearrangement of Oxonium Ylides: Synthetic Applications and Mechanistic Studies
DownloadSpring 2016
The Stevens [1,2]-rearrangement of onium ylides has been employed as a valuable synthetic method to construct new C-C bonds. Oxonium ylides are reactive intermediates that undergo facile Stevens rearrangement under mild conditions. In the last several decades, the Stevens rearrangement of oxonium...
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The construction of diverse nitrogen-containing heterocycles via the reaction of amines of azides with metallocarbenes
DownloadFall 2011
A fundamental goal in organic chemistry is the development of new and innovative ways of transforming simple building blocks into complex structures. The formation of ylides from the reaction of metallocarbenes with heteroatoms, such as the nitrogen of an amine or azide, is an example of a...
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Spring 2014
Fluorous phase chemistry is an emerging field in terms of new separation techniques. A highly fluorinated compound tends to dissolve in a fluorinated solvent rather than in a common organic solvent. Fluorophilic solid phase separation (F-SPE) techniques are also well established. Our goal is to...
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Fall 2012
5-Membered carbocycles are ubiquitous in natural products and synthetic drugs. Methods of generating them are therefore valuable, and the ability to do so in a stereospecific and enantioselective manner while making considerable gains in molecular complexity with additional incorporation of...