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- 10West, Frederick (Chemistry)
- 1Bennet, Andy (SFU Chemistry)
- 1Cambpell, Robert (Chemistry)
- 1Hall, Dennis (Chemistry)
- 1Lowary, Todd (Chemistry)
- 1Lucy, Charles (Chemistry)
- 1Ahmed Hamdy Mahmoud Elmenoufy
- 1Bonderoff, Sara A
- 1Bott, Tina Marie
- 1Dunbar, Christine R
- 1Fradette, Ryan J
- 1Hosseini, Seyedeh Nargess
- 2Interrupted Nazarov reaction
- 2Nazarov reaction
- 1Allylic alcohol transposition
- 1Alternative Nazarov reaction
- 1Aluminum enolate oxidation
At present, the number of cancer patients who develop resistance to conventional cancer therapeutics, such as DNA damaging chemotherapeutics, or radiotherapy, is increasing. A major reason for developing such resistance is that cancer cells have the ability to repair their DNA damage caused by...
Diastereomeric piperidinium salts were prepared as substrates for the Stevens [1,2]-rearrangement of ammonium ylides, the key step in a proposed synthetic route towards lysergic acid, a valuable compound in medicinal and synthetic chemistry. Because of unexpected reactivity seen in the alkylation...
This dissertation expands the scope and understanding of the Nazarov electrocyclization and interception of the reactive cyclopentenyl cation intermediate that is formed though a 4π electrocyclization of a pentadienyl cation. An intermolecular process for interrupting the Nazarov is discussed....
Five-membered carbocycles are highly prevalent motifs in natural products and pharmaceutical drugs. Finding routes towards these moieties has been an attractive area of pursuit in synthetic organic chemistry. The Nazarov reaction is one that has been widely used to access cyclopentenone...
Synthesis of Lipopolysaccharide O-antigens from Klebsiella pneumoniae Serotype O2a as Molecular Probes for Biosynthetic StudiesDownload
Many Gram-negative bacteria are pathogenic organisms that can cause disease and death. As antibiotic resistance and nosocomial disease occurrences both increase, these infections are becoming more problematic. These issues can be partially attributed to lipopolysaccharide (LPS), which is a major...
Synthesis of Medium-Sized Oxygen and Nitrogen Heterocycles via Stevens Rearrangement of Sulfonium Ylides and Formal Synthesis of (+)-LaurencinDownload
Medium-sized cyclic ether and amine motifs often constitute the framework of a variety of natural products with interesting biological activities. As a result, the construction of these heterocycles is an important subject in organic synthesis, which has triggered the development of many...
Synthetic Studies Towards (+)-Dactylol Utilizing an Oxonium Ylide Rearrangement and Related Studies.Download
Dactylol is a structurally interesting sesquiterpene natural product. One of its key structural features is an the eight-membered ring. The challenges of synthesizing an eight membered ring are discussed in Chapter 1. In addition, various methods for generating an eight-membered ring are...
The Stevens [1,2]-rearrangement of onium ylides has been employed as a valuable synthetic method to construct new C-C bonds. Oxonium ylides are reactive intermediates that undergo facile Stevens rearrangement under mild conditions. In the last several decades, the Stevens rearrangement of oxonium...
The construction of diverse nitrogen-containing heterocycles via the reaction of amines of azides with metallocarbenesDownload
A fundamental goal in organic chemistry is the development of new and innovative ways of transforming simple building blocks into complex structures. The formation of ylides from the reaction of metallocarbenes with heteroatoms, such as the nitrogen of an amine or azide, is an example of a...
5-Membered carbocycles are ubiquitous in natural products and synthetic drugs. Methods of generating them are therefore valuable, and the ability to do so in a stereospecific and enantioselective manner while making considerable gains in molecular complexity with additional incorporation of...