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Inhibition Studies of DapL Enzymes Orthologs and Synthesis of Proposed Biosynthetic Intermediates of Tabtoxin and Synthesis of a Hexaketide as a Standard for Lovastatin Studies
DownloadFall 2017
The enzyme LL-diaminopimelate aminotransferase (DapL) catalyzes the transformation of L-THDP to LL-DAP during the biosynthesis of lysine in plants, alga, and in some pathogenic bacteria like Leptospira interrogans and Verrucomicrobium spinosum. Because the biosynthesis of lysine is absent in...
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Fall 2018
Pyridoxal phosphate (PLP)-independent racemases, enzymes that are cofactor and metal free invert, the configuration at the α-carbon of amino acids. In nature, diaminopimelate epimerase (DapF), glutamate racemase (GluR), aspartate racemase (AspR), proline racemase (ProR), O-ureidoserine racemase...