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Skip to Search Results- 2Xenotransplantation
- 1Anti-CD154 monoclonal antibody
- 1Anti-CD45RB monoclonal antibody
- 1Anti-LFA-1 monoclonal antibody
- 1DR80
- 1Diabetes Mellitus
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Co-transplantation of neonatal porcine islets with Sertoli cells combined with short-term monoclonal antibody therapy in preventing neonatal porcine islet xenograft rejection
DownloadFall 2009
The need for an unlimited source of islets and a safer method of immunosuppression has limited the widespread application of islet transplantation. To remedy the shortage of donor tissue, xenotransplantation of neonatal porcine islets (NPI) has been proposed. In this study we sought to determine...
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Evaluation of the Protection Induced by a Monotherapy of Anti-LFA-1 Monoclonal Antibody and Co-transplantation of Neonatal Porcine Islets with Sertoli Cells
DownloadSpring 2012
Two major barriers to islet transplantation are the need for an unlimited source of donor tissue and a safer method of immunosuppression. These may be overcome by xenotransplantation of neonatal porcine islets (NPI) along with combined co-transplantation of neonatal porcine Sertoli cells (SC)...
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Neonatal Porcine Islet Xenotransplantation: Non-invasive in vivo imaging and basic islet biology
DownloadFall 2022
Islet transplantation has been proven as a successful clinical therapy for diabetes; however, its widespread use is limited by multiple factors including a shortage of human donors, the need for long term immunosuppression and difficulty with graft monitoring post transplantation. Pig islet...
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The potential of novel small inhibitory molecules to prevent the rejection of neonatal porcine islets in mice
DownloadFall 2011
The objectives of this study were to determine the effect of small inhibitory molecules suramin and DR80 on T cell proliferation in vitro as well as in vivo by preventing the rejection of neonatal porcine islets (NPI) in mice when combined with anti-LFA-1 monoclonal antibody (mAb). Suramin and...