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- 2Alternative oxidase
- 1Alternative oxidase, AOX, Neurospora crassa, AOX deficient mutants, possible AOX assembly mutants
The TOB (Topogenesis of Outer membrane β-barrel proteins) complex is composed of the core proteins Tob55 (Sam50), Tob37 (Sam37) and Tob38 (Sam35). The complex facilitates the insertion of all β-barrel and some α-helically anchored integral proteins into the mitochondrial outer membrane (MOM)....
When chemical inhibitors or mutations impair the standard mitochondrial electron transport chain (sETC) in Neurospora crassa, alternative oxidase (AOX) is induced. AOX transfers electrons directly from coenzyme Q to oxygen, thus bypassing the later steps of the sETC. In N. crassa AOX is encoded...
Investigation of transcriptional and translational regulation of the Neurospora crassa alternative oxidaseDownload
Mitochondria are organelles found in most eukaryotes and supply the cell with the majority of its energy needs in the form of ATP. Most of the proteins needed for mitochondrial function are nuclear encoded. Therefore, mitochondria communicate their functional status to the nucleus, resulting in...
Not Simply the Induction of Alternative Oxidase: The AOD2 and AOD5 Transcription Factors Play Roles in Regulation of Metabolism and Energy Production in Neurospora crassaDownload
Mitochondria are important organelles in most eukaryotic organisms as they supply the majority of the ATP needed for cellular functions. Although mitochondria contain their own DNA, the vast majority of mitochondrial proteins are encoded in the nucleus. Thus, when mitochondria experience stress...
The role of YVH1, a dual specificity phosphatase, in the production of alternative oxidase in the filamentous fungus Neurospora crassaDownload
Alternative oxidase (AOX) is a single protein enzyme that carries electrons from ubiquinol to molecular oxygen. AOX is induced in many organisms, including Neurospora crassa, when the standard electron transport chain is blocked through various inhibitors or mutations. A knockout (KO) for a dual...
The role of the ERMES complex in the assembly of mitochondrial outer membrane proteins in the filamentous fungus Neurospora crassaDownload
The ERMES (endoplasmic reticulum-mitochondria encounter structure) is composed of the Mdm10, Mdm12, Mmm1 and Mmm2 proteins, and acts as a tether between mitochondria and the endoplasmic reticulum (ER). Mutations affecting any of the proteins in the structure are associated with a variety of...