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A Method to Enhance Re-Endothelialization of Tissue Engineered Decellularized Allograft Heart ScaffoldsDownload
Allograft tissue is used to reconstruct cardiac birth defects but induces an immune response resulting in allo-sensitization. Decellularization reduces the immune response, however, acellular vascular tissue is thrombogenic. In-vitro endothelialization may attenuate thrombogenicity. Here we offer...
Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet TransplantationDownload
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
Mesenchymal stem cells (MSCs) have immuno-regulatory, anti-inflammatory, and pro-angiogenic properties through the secretion of a myriad of trophic factors, and have been shown to have a beneficial effect on graft function. In this thesis we investigated whether MSCs’ have an effect on neonatal...
Diabetes is a chronic metabolic condition characterized by hyperglycemia resulting from impaired glucose metabolism. Type 1 diabetes mellitus (T1DM) is a result of progressive autoimmune destruction of insulin-producing pancreatic beta (β)-cells. By far, parenteral insulin replacement is...
Type 1 diabetes mellitus (T1DM) is a chronic disorder of glucose metabolism due to autoimmune destruction of insulin producing β-cells. Although insulin therapy is the standard treatment for T1DM, islet transplantation, which has emerged as an alternative to insulin injection, offers a more...
Paracrine signaling within the pancreatic islets is important for the normal secretion of insulin and glucagon. As the secretion of insulin and glucagon are central to whole body glucose homeostasis, paracrine signaling in the islet has a role in glucose control. Genetic animal models have shown...