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- 1Alcohol
- 1Alcohol activation
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- 1Carboxylic acid activation
- 1Catalysis
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Breaking New Ground with the Suzuki-Miyaura Reaction: Stereoselective Cross-Couplings of 1,1-Diboronyl Alkanes
DownloadFall 2015
Synthetic organic chemistry is an area that has seen incredible growth through the years. The level of molecular complexity that can be achieved through available synthetic methods today is remarkable. Still, as the field continues to progress, increasing focus is being placed upon the strategic...
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Fall 2011
Propargylic alcohol natural products are found in many species of terrestrial plants and marine organisms. Because these compounds are usually isolated from the natural source in only small amounts, few studies of propargylic alcohol natural products have been conducted to date. Nevertheless,...
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Greener Chemistry Using Boronic Acids as Organocatalysts and Stoichiometric Reaction Promoters
DownloadFall 2012
Catalysis is crucial for society in view of producing pharmaceutical agents and commodity chemicals. Industry and academia alike are constantly searching for organic transformations which can not only efficiently produce important pharmaceuticals and commodity chemicals, but can also do so in a...
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Mild, Green and Catalytic: Ortho-Iodoarylboronic Acids for Direct Amide Bond Formation at Room Temperature
DownloadSpring 2011
Although the thermal direct formation of amide bonds has been known since 1858, the mechanism of the reaction remains poorly understood and is still a major scientific issue. The direct reaction between amines and carboxylic acids generates a thermodynamically stable ammonium carboxylate salt. In...
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Preparation of Polysubstituted Pyrans Toward the Synthesis of Biologically Active Compounds
DownloadSpring 2016
Polyfunctionalized pyrans are among the most common structures in bioactive molecules. Based on the ubiquity of the pyran framework in natural and synthetic molecules, there is a need to develop more efficient methods of synthesizing and functionalizing the pyran motif. Due to recent interest in...
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Spring 2020
Polyhydroxylated compounds such as carbohydrates, glycerols and diols play an important role in biological chemistry and as pharmaceutical agents. Furthermore, diols are often useful starting materials and intermediates to prepare stereochemically complex molecules. However, hydroxy group...