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Mild, Green and Catalytic: Ortho-Iodoarylboronic Acids for Direct Amide Bond Formation at Room Temperature
DownloadSpring 2011
Although the thermal direct formation of amide bonds has been known since 1858, the mechanism of the reaction remains poorly understood and is still a major scientific issue. The direct reaction between amines and carboxylic acids generates a thermodynamically stable ammonium carboxylate salt. In...
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