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- 1Bhakta, Urmi Bhusan
- 1Elford, Timothy
- 1Hackney, Hannah
- 1Kwok, Samantha, P
- 1McDonald, Rory
- 1Mo, Xiaobin
In the Introduction of this thesis, consideration is given to historical and ongoing value of investing research efforts in the total synthesis of natural products. Following this discussion is an explanation of the factors that guided the selection of palmerolide A as a synthetic target. The...
A unique borylative migration of heterocyclic enol perfluorosulfonates has been developed to access six-membered heterocyclic α-substituted allylboronates in a stereoselective and efficient manner. The synthetic utility of the allylboronate intermediates was demonstrated by a highly...
Rosette Nanotubes (RNTs) are a class of self-assembled organic nanomaterials generated through the spontaneous hierarchical organization of guanine-cytosine (G˄C) bases with a built-in self-assembling ability. Driven by non-covalent intermolecular forces in solution, G˄C bases self-assemble into...
The field of organic chemistry has seen remarkable advances throughout the decades. Of all advances, catalysis is playing a crucial role, since it can lower the activation energy of normally inert starting materials for further chemical reactions. In this context, the catalytic direct activation...
Asymmetric allylboration is a very useful and potent method for the synthesis of chiral homoallylic alcohols, a structural motif present in many natural products and biologically relevant molecules. B/Si double-allylation reagents have also been reported that can lead to chiral homoallylic...
Organic chemistry has its foundations in the 19th century; since, it has grown into a number of industries affecting our daily lives such as the manufacture of goods and life saving pharmaceuticals. The need for new and increasingly efficient synthetic methods has grown in response to the...
Novel Aromatic Boron-Nitrogen Heterocycles: Synthesis, Properties and Applications in Biomedicine and OptoelectronicsDownload
Heterocyclic chemistry often calls for an interdisciplinary approach to research. Novel structures invite study from both a fundamental and applied standpoint, and a given scaffold may have properties relevant to synthesis, medicine, catalysis, optoelectronics, and more. In recent decades, boron...
Preparation and Application of Cyclic Chiral Organoboron Compounds for the Stereoselective Synthesis of Vacquinol-1 Analogs, and Trisubstituted CyclobutylboronatesDownload
Boron is a versatile atom in synthetic organic and medicinal chemistry. The formation of a variety of carbon-carbon and carbon-heteroatom bonds, and the ability to act as a pharmacophore makes boron a powerful tool in drug discovery. An area of drug discovery that remains underexplored with boron...
Synthesis of Lipopolysaccharide O-antigens from Klebsiella pneumoniae Serotype O2a as Molecular Probes for Biosynthetic StudiesDownload
Many Gram-negative bacteria are pathogenic organisms that can cause disease and death. As antibiotic resistance and nosocomial disease occurrences both increase, these infections are becoming more problematic. These issues can be partially attributed to lipopolysaccharide (LPS), which is a major...
The pradimicins are natural products that are both structurally intriguing to a synthetic chemist and possess biological activity as antifungal and antiviral agents. Our interest towards designing a synthetic route for these compounds and various analogues was sparked by the potential to produce...