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Skip to Search Results- 1Dandapat, Arpan
- 1Ebesoh, Njuacha
- 1Hunter, Carmanah
- 1Key, Jessie Adam
- 1Khanna, Neha
- 1Sadek, Christopher
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Fall 2014
Oxime ligation is an effective conjugation strategy for biomolecules and polymers in aqueous solution. The reaction is chemoselective, joining an aldehyde or ketone electrophile with an aminooxy nucleophile. The oxime linkage is thermally and hydrolytically stable under most biological...
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Fall 2023
The human immune system is a network that is crucial to fight against infections and foreign pathogens. It is divided into innate system, which is the first line of defense, and adaptive immune system, which is more specific. The specificity and long-lasting nature of the adaptive immune system...
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Spring 2011
The lymphocyte function associated antigen-I (LFA-1) is important to a variety of immune cell processes including immune synapse formation and lymphocyte homing. Studies have shown that lymphocytes exhibit increased adhesion upon sialic acid removal by neuraminidase. Recent studies of β1 integrin...
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Fluorogenic and fluorescent bioorthogonal labelling strategies for examining glycoproteins and phospholipids
DownloadFall 2012
Traditional genetically-encoded imaging strategies are problematic for use in analysing cell surface interactions due to the heterogeneous nature of the cell surface, and the high level of post-translational modifications. Small molecule fluorophores can provide dynamic information on cell...
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Spring 2020
Sialic acids are an incredibly diverse family of carbohydrates that serve many roles in biological systems. Their presentation is influenced not only by structural modification of the sialic acid, but also by attachment through glycosidic linkages and their presence on different glycoconjugates....
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Probing the function of LFA-1 using fluorescent proteins that target the beta-2 integrin transmembrane domain
DownloadSpring 2011
The lymphocyte functional antigen-1 (LFA-1) is a type I heterodimeric transmembrane (TM) proteins involved in cell adhesion, and mediates a number of cellular and physiological processes. In this work, we used recombinant fluorescently-tagged proteins derived from the TM domain of the β2 integrin...
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Fall 2014
Neuraminidase enzymes (NEU) catalyze the cleavage of sialic acid residues from sialylated oligosaccharides, glycoproteins, and glycolipids. The human neuraminidase enzymes (hNEU) are a family of four isoenzymes (NEU1, NEU2, NEU3, and NEU4), which cleave terminal sialic acid groups...