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Characterizing endocannabinoid system development in zebrafish and investigating cannabidiol-mediated downregulation of the Sonic Hedgehog PathwayDownload
Cannabis is the most frequently used recreational drug during pregnancy. Nearly 4% of American women self-reported use during their pregnancies in 2014, which represents a 62% increase from 2002. The compounds in cannabis are mediated through interactions with the endocannabinoid system (ECS),...
Elucidating the roles of endocannabinoid signalling pathway in motor neuron and locomotor development in zebrafish early lifeDownload
The major endocannabinoids (eCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG) mediate their effects through their actions on cannabinoid receptors (CBRs), mainly via CB1R and CB2Rs. The predominant catabolic regulators that degrade AEA and 2-AG are fatty acid amide hydrolase (FAAH) and...
Glutamate AMPA receptors (AMPARs) are major excitatory receptors in the vertebrate CNS. In many biological systems there are changes in the properties of AMPARs during development that are essential for providing an increase in efficiency of information transfer between neurons and a refinement...
Retinoic acid prevents alteration of neuronal morphology and locomotion of zebrafish embryos induced by ethanol exposure during gastrulationDownload
Ethanol (EtOH) exposure during development has been shown to lead to deficits in fine and gross motor control. In this study I used zebrafish embryos in the gastrulation stage to determine the developmental effects of a brief, 5-hour exposure to EtOH. I treated fertilized zebrafish eggs from 5.25...
The Expression of Transmembrane AMPA Receptor Regulatory Proteins (TARPs) in Developing Zebrafish (Danio rerio)Download
In embryonic vertebrates, newly-formed synapses are quiet until they are unsilenced through a process that resembles synaptic plasticity but remains mechanistically unclear. I used gene expression to determine if Transmembrane AMPA Receptor Regulatory Proteins (TARPs), AMPA receptor auxiliary...
The escape response in zebrafish is mediated in part by the Mauthner cell and its two homologues, MiD2cm and MiD3cm. In adult fish, the Mauthner cell fires a single action potential when activated while the homologues fire multiple action potentials. Their distinct firing properties are partially...