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Discovery and Targeted Approaches for Comparative Label-Free Proteomic Quantification via Mass Spectrometry
DownloadSpring 2023
Over the last few decades, the field of proteomics has developed rapidly owing to advancements in genomic and transcriptomic technologies contributing to the compilation of vast quantities of protein sequence libraries. Proteomics, the study of global protein composition in a biological system,...
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Molecular and cellular roles of the N-end rule pathway in apoptotic cell death in mammalian-derived cell lines
DownloadFall 2017
Cellular stresses and signaling that lead to the initiation of apoptotic pathways often result in the activation of proteases such as caspases which in turn culminate in the generation of proteolytically activated protein fragments with new or altered roles. Recent work has revealed that the...
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Fall 2012
In Escherichia coli, the enzyme RelA catalyses the synthesis of (p)ppGpp in response to amino acid starvation. RelA activation requires the codon specific binding of a deacylated tRNA to the ribosomal A-site. By a poorly understood regulatory mechanism, RelA alternates between an inactive...