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- 38Medicine and Dentistry, Faculty of/Alberta Research Centre for Health Evidence (ARCHE)
- 35Medicine and Dentistry, Faculty of/Journal Articles (Medicine and Dentistry)
- 9Oncology, Department of
- 9Oncology, Department of/Medical Physics
- 5University of Alberta Library
- 22Hartling, L.
- 17Klassen, T. P.
- 11Hartling, Lisa
- 11Schulz, Richard
- 9Babenko, Oksana
- 9De Zanche, Nicola
- 12Systematic reviews
- 10Pediatrics
- 5Child health
- 5Meta-analysis
- 5Randomized controlled trials
- 4Drug therapy
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2009-01-01
Joffe, Ari R., Schulz, Christina, Rosychuk, Ronda J., Dyck, John, Rebeyka, Ivan M., Ross, David B., Cheung, Po-Yin, Schulz, Richard
During cardiopulmonary-bypass matrix-metalloproteinases released may contribute to ventricular dysfunction. This study was to determine plasma matrix-metalloproteinases in neonates after cardiopulmonary-bypass and their relation to post-operative course. A prospective observational study included...
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Quantifying bias in randomized controlled trials in child health: a meta-epidemiological study.
Download2014
Hartling, L., Vandermeer, B., Dryden, D. M., Fernandes, R. M., Hamm, M. P.
Objective: To quantify bias related to specific methodological characteristics in child-relevant randomized controlled trials (RCTs). Design: Meta-epidemiological study. Data Sources: We identified systematic reviews containing a meta-analysis with 10–40 RCTs that were relevant to child health in...
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Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk
Download2014-01-01
Huyard, Fanny, Yzydorczyk, Catherine, Castro, Michele M., Cloutier, Anik, Bertagnolli, Mariane, Sartelet, Hervé, Schulz, Richard, Nuyt, Anne Monique
Neonatal high-oxygen exposure leads to elevated blood pressure, microvascular rarefaction, vascular dysfunction and arterial (aorta) rigidity in adult rats. Whether structural changes are present in the matrix of aorta wall is unknown. Considering that elastin synthesis peaks in late fetal life...
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Research Briefs as Communication and Motivation Tools: Knowledge Translation in Medical Education
Download2017-12-10
Babenko, Oksana, Nadon, Lindsey, Ding, Mao, Daniels, Lia
Medical learners are critical stakeholders in medical education research – they are both research participants and end-users of research findings. Traditional forms of disseminating research findings may take years to produce and may never be accessed by participants. Despite this, medical...
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2008
Russell, K., Liang, Y., O'Gorman, K., Klassen, T. P., Friesen, C., Dryden, D. M., Wild, T. C., Durec, T.
Background: Methamphetamine (MA) is a potent stimulant that is readily available. Its effects are similar to cocaine, but the drug has a profile associated with increased acute and chronic toxicities. The objective of this systematic review was to identify and synthesize literature on risk...
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Risk of bias versus quality assessment of randomised controlled trials: cross sectional study.
Download2009
Dryden, D. M., Krebs Seida, J., Ospina, M., Hooton, N., Hartling, L., Klassen, T. P., Liang, Y.
Objectives To evaluate the risk of bias tool, introduced by the Cochrane Collaboration for assessing the internal validity of randomised trials, for inter-rater agreement, concurrent validity compared with the Jadad scale and Schulz approach to allocation concealment, and the relation between...
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Sequential fractionation and isolation of subcellular proteins from tissue or cultured cells
Download2015-01-01
Baghirova, Sabina, Hughes, Bryan G., Hendzel, Michael J., Schulz, Richard
Many types of studies require the localization of a protein to, or isolation of enriched protein from a specific cellular compartment. Many protocols in the literature and from commercially available kits claim to yield pure cellular fractions. However, in our hands, the former often do not work...
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Smooth muscle NOS, colocalized with caveolin‐1, modulates contraction in mouse small intestine
Download2008-01-01
Daniel, Edwin E., El‐Yazbi, Ahmed F., Cho, Woo Jung, Cena, Jonathan, Schulz, Richard
Neuronal nitric oxide synthase (nNOS) in myenteric neurons is activated during peristalsis to produce nitric oxide which relaxes intestinal smooth muscle. A putative nNOS is also found in the membrane of intestinal smooth muscle cells in mouse and dog. In this study we studied the possible...